Results 151 to 160 of about 169,768 (264)

Probing 3‐Amino‐2H‐Azaindazoles as Allosteric Inhibitors of the Protein Tyrosine Phosphatase SHP2

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
A palladium‐catalyzed domino reaction facilitated the discovery and rapid synthesis of selective, potent 3‐amino‐2H‐azaindazole derivatives serving as allosteric inhibitors of SHP2. Structural analysis via co‐crystallography confirmed binding at the allosteric site, thereby stabilizing the autoinhibited SHP2 conformation, qualifying this scaffold as a ...
Machoud Amoussa, Nina‐Louisa Efrém, Feng Li, Ziqiong Guo, Yvette Roske, Katrin Jana Frank, Szymon Pach, Clemens Alexander Wolf, Feng Bo, Marina Lesina, Mika Kintzel, Rana Alsalim, Victoria Zeitz, Noémi Csorba, Silke Radetzki, György M. Keserű, Oliver Daumke, Hana Algül, Gerhard Wolber, Jia Li, Marc Nazaré   +20 more
wiley   +1 more source

The complete chloroplast genome and phylogenetic analysis of <i>Fraxinus paxiana</i> Lingelsh. 1907 (Oleaceae). [PDF]

Mitochondrial DNA B Resour
Feng H, Sun W, Meng X, Chen S.
europepmc   +1 more source

A Novel CsYABBY3‐CsAS1 Feedback Loop Coordinates Trichome Differentiation and Cannabinoid Biosynthesis in Cannabis sativa L.

Advanced Science, Volume 13, Issue 34, 19 June 2026.
A novel transcriptional module involving CsYABBY3 and CsAS1 is identified to regulate cannabinoid biosynthesis and trichome development. These factors mutually activate each other and form a protein complex via a conserved residue, acting synergistically to amplify metabolic flux through a coordinate feed‐forward mechanism.
Xuewen Zhu, Yaolei Mi, Xue Cao, Weiqiang Chen, Pucheng Fan, Jing Wang, Yiming Zhang, Wei Yang, Huihua Wan, Shanshan Chen, Xiangxiao Meng, Jun Li, Shuo Shen, Mingkun Huang, Xiaoyu Zhang, Ming Luo, Shilin Chen, Zhichao Xu, Wei Sun   +18 more
wiley   +1 more source

Protein NS4A of ZIKV Inhibits Glycolytic Flux by Targeting Enolase-1. [PDF]

Curr Issues Mol Biol
Ma R, Zhang K, Qi Z, Wang L, Fu QB.
europepmc   +1 more source

Advances in anti-dengue virus properties of Traditional Chinese Medicines. [PDF]

Front Microbiol
Zeng R, Wu T, Zheng K, Zhang L, Sun F, Yuan S, Huang S, Wang F, Dai Z, Zhou J, Li S, Hu D, Shi Y, Dai J.   +13 more
europepmc   +1 more source

Traditional Respiratory Remedies From Anatolia: Ethnobotanical Insights and Bioactive Properties

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
ABSTRACT Respiratory disorders, ranging from acute viral infections such as influenza and bronchitis to chronic inflammatory conditions including chronic obstructive pulmonary disease, asthma, emphysema, and pneumonia, represent a major global health burden, affecting millions annually. Traditional Anatolian folk medicine has long relied on plant‐based
Golshan Zare, Yağmur Diker, Irem Tatlı Çankaya, Emran Habibi, Satyajit D. Sarker, Lutfun Nahar   +5 more
wiley   +1 more source

MATERIAS

, 1991
openaire   +1 more source

Ensemble Modeling of Shifts in the Suitable Distribution and Ecological Niche of the Alpine Tibetan Medicinal Herb Corydalis hendersonii Hemsl. Under Climate Change and Human Activity

Ecology and Evolution, Volume 16, Issue 6, June 2026.
Corydalis hendersonii, a rare alpine Tibetan medicinal herb, faces increasing threats from climate warming and intensified human activity. Using a biomod2 ensemble species distribution model that integrates climate variables and the Human Footprint Index, we predict that suitable habitats will remain stable or slightly expand under SSP126 but contract ...
Dehua Wu, Yanlei Liu, Zhixian Jing, Siqi Liu, Ba Qiang, Weiwu Chen, Yiheng Wang, Chuanzhi Kang, Zekun Zhang   +8 more
wiley   +1 more source

The problem of the mechanical surface tension of active Brownian particle interfaces. [PDF]

Proc Natl Acad Sci U S A
García RF, Chacón E, Tarazona P, Valeriani C.   +3 more
europepmc   +1 more source

Mesenteric Adipose Tissue as a Modulator of Intestinal Inflammation: Mechanistic Insights and Model Systems in Crohn's Disease

European Journal of Immunology, Volume 56, Issue 6, June 2026.
This review explores how mesenteric adipose tissue, particularly creeping fat, contributes to intestinal inflammation through dysregulated adipokine signalling. We explore how metabolic stress alters immune‐adipose interactions and promotes disease progression.
Toka Omar, Carl Weidinger, Britta Siegmund   +2 more
wiley   +1 more source