Results 61 to 70 of about 837,030 (218)
Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators
Angewandte Chemie, EarlyView.The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia +20 more
wiley +2 more sources
, 2020 Emotional intelligence also determines a person's success. Emotional intelligence is an ability such as self-motivating ability, enduring to frustration, regulating mood so that stress loads don't paralyze thinking, and empathize.
Nasution, Sri Lestari
core +1 more source
Advanced Science, EarlyView.We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang +19 more
wiley +1 more source
Ingeniería Industrial, 2019 El trabajo del desarrollo agroindustrial de la quinua se basa en las siguientes variables: producto transformado, nivel de procesamiento, variedades de la materia prima y procedencia de la materia prima.
Rubén Wilfredo Jilapa Humpiri
doaj +1 more source
Advanced Science, EarlyView.Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang +9 more
wiley +1 more source
Logística reversa, reutilização e trabalho social na moda
ModaPalavra e-periódico, 2014 O produto de vestuário desenvolvido de acordo com o sistema de moda tem um ciclo de vida curto. Da matéria-prima ao descarte, os impactos ambientais gerados pelos produtos de moda têm sido estudados visando minimizar as consequências para o meio ambiente.
Neide Köhler Schulte +3 more
doaj +2 more sources
Method validation for the quantification of fluconazole and its organic impurities in raw material using high-performance liquid chromatography [PDF]
Biomedica, 2023 Castillo JA, Afanasjeva N.
europepmc +1 more source
Advanced Science, EarlyView.Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren +11 more
wiley +1 more source
Engineering Borophene Band Structure Through Thickness
Advanced Science, EarlyView.Borophene grown on W(110) shows a thickness‐dependent evolution of its structural and electronic properties. Surface microscopy, diffraction, XPS, and ARPES reveal distinct monolayer and bilayer phases. The formation of the second layer is accompanied by structural reconstruction, changes in chemical properties, and new ARPES features, demonstrating ...
Matteo Jugovac +4 more
wiley +1 more source
Magnetic ordering and its influence on X‐ray spectroscopies
Major Reference Works, Page 163-168., 2023 International Tables for Crystallography is the definitive resource and reference work for crystallography and structural science.
Each of the eight volumes in the series contains articles and tables of data relevant to crystallographic research and to applications of crystallographic methods in all sciences concerned with the ...
Gerrit van der Laan +3 more
wiley +1 more source