Results 121 to 130 of about 27,564,907 (327)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

İç Mimarlık Eğitiminde Deneyim Odaklı Malzeme Öğrenimi Üzerine

open access: yesPLANARCH - Design and Planning Research
İç mimarın malzeme bilgisi, tasarlanan mekânın işlevselliğini, estetiğini, sürdürülebilirliğini ve genel başarısını doğrudan etkilemektedir. İç mekân tasarımında atmosfer ve konfor sağlayan doğru malzemeyi seçmek, doğru uygulama bilgisini ve malzemenin ...
Bilge Sayıl Onaran   +1 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Reflectance Hashing for Material Recognition

open access: yes, 2015
We introduce a novel method for using reflectance to identify materials. Reflectance offers a unique signature of the material but is challenging to measure and use for recognizing materials due to its high-dimensionality.
Dana, Kristin, Nishino, Ko, Zhang, Hang
core   +1 more source

The Technical Dimension of the Works of Artists Robert Rauschenberg and Jasper Johns

open access: yesمجلة فنون البصرة
The research entitled (The Technical Dimension of the Works of Artists Rauschenberg and Jasper Jones) dealt with the nature of the concept of technology and the mechanisms of its operation in plastic art, The research come in four chapters.
Nawras Hameed Majeed
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Material properties of nanoclay PVC composites [PDF]

open access: yes, 2009
Nanocomposites of poly(vinyl chloride) have been prepared using both hectorite- and bentonite-based organically-modified clays. The organic modification used is tallow-triethanol-ammonium ion.
Awad, Walid   +7 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Long-term material compatibility testing system [PDF]

open access: yes, 1973
System includes procedure for hermetically sealing solid materials and fluids in glass ampoule and use of temperature-controlled facility containing sample holder, which permits sample containers to be retrieved safely and conveniently.
Griffin, D. C., Jr.   +3 more
core   +1 more source

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