Results 61 to 70 of about 164,066 (268)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Constants of Metal Rubber Material

Modern Applied Science, 2014
Damping materials made of pressing wire, such as Metal Rubber (MR material), “metal-flex”, “spring cushion” etc. are used widely in vibration protection systems. They have high strength and damping, however they are non-linear and anisotropic. To use contemporary finite element software for calculation of vibration insulators made of wire damping ...
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Simulation of metal creep in nonstationary complex stress state

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2019
The simulation of the results of metal testing under creep conditions at the nonstationary complex stress state is considered. As an example, we consider the experimental data obtained by a group of Japanese scientists for testing tubular samples of ...
Alexander Mikhaylovich Lokoshchenko, Leonid Viktorovich Fomin, Yuriy Genrikhovich Basalov, Vardan Samvelovich Agababyan   +3 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Optimization the working parameters of as-forged 42CrMo steel by constitutive equation-dynamic recrystallization equation and processing maps

Journal of Materials Research and Technology, 2020
42CrMo steel belongs to low-alloy medium carbon steel and also belongs to ultra-high-strength steel. In this study, thermal compression tests (800°C - 1200°C, 0.01s-1 - 10s-1) and subsequent calculations proved that many material constants of 42CrMo ...
Hongchao Ji, Hailong Duan, Yaogang Li, Wangda Li, Xiaomin Huang, Weichi Pei, Yonghao Lu   +6 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Giant Dielectric Constant Materials and Their Applications

, 2012
There is a constant need in the modern electronic industry for capacitors with high capacity per volume in order to use in many applications such as memories devices, energy storage, microwave filters, among others. The synthesis, characterization and study of materials with a very high or giant dielectric constant are in particular important and have ...
Varela, José A., Orlandi, Marcelo O., Ramirez, Miguel A., Foschini, Cesar R., Felix, Anderson A.   +4 more
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Anisotropic viscoelastic constitutive law assuming plane stress state

Mechanical Engineering Journal
The viscoelastic material constitutive law based on the anisotropic generalized Maxwell model, which assumes a three-dimensional (3D) stress state, is reduced to a plane-stress state to efficiently analyze thin plate-like laminated structures.
Koji YAMAMOTO, Norio HIRAYAMA, Kenjiro TERADA   +2 more
doaj   +1 more source