Results 141 to 150 of about 3,960,500 (346)

Pedagogies of Race: The Politics of Whiteness in an African American Studies Course [PDF]

open access: yes, 2011
This paper evaluates students\u27 arguments for a color-blind society to avoid discussions related to the continued existence of racism in USA culture.
Jones, Regina V.
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Cremation Site 7 (Excavation 4.1), Southern Suburb of Taurica Chersonesos

open access: yesНижневолжский археологический вестник
During a comprehensive exploration of the Southern suburb of Tauric Chersonesos in 2021–2023, about 340 cremation sites were discovered; those were designated locations where the bodies of the deceased buried in the necropolis were burned according to ...
Viktor V. Kropotov, Viktor V. Vakhoneev
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Subjectivity and the Cultural Constraints of Academic Literature in Material Culture: An Investigation into the Discussion of Pattern and Symbol in Persian Carpets [PDF]

open access: yes, 2012
This paper examines the academic literature on material culture, focusing on inherent cultural standpoints within the European tradition and the impossibility of arriving at an objective position.
Rad, Fatemeh Safaii
core  

Home - About - Disclaimer - Privacy