Results 101 to 110 of about 16,620,600 (346)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Three-dimensional free vibration analysis of thermally loaded fgm sandwich plates [PDF]
, 2020 Using the finite element code ABAQUS and the user-defined material utilities UMAT and UMATHT, a solid brick graded finite element is developed for three-dimensional (3D) modeling of free vibrations of thermally loaded functionally gradient material (FGM)
Burlayenko, V. N. +2 more
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Material Efficiency of Building Construction
Buildings, 2014 Better construction and use of buildings in the European Union would influence 42% of final energy consumption, about 35% of our greenhouse gas emissions and more than 50% of all extracted materials.
Antti Ruuska, Tarja Häkkinen
doaj +1 more source
Silicon solar cell efficiency improvement: Status and outlook [PDF]
Efficiency and operating life is an economic attribute in silicon solar cells application. The efficiency improvements made during the 30 year existence of the silicon solar cells, from about 6% efficiency at the beginning to 19% in the most recent ...
Wolf, M.
core +1 more source
Experimentally based numerical models and numerical simulation with parameter identification of human lumbar FSUs in traction [PDF]
, 2004 Numerical simulation of the behaviour of human lumbar spine segments, moreover, parameter-identification of the component organs of human lumbar FSUs are presented in traction therapies, by using FEM analysis. First, a simple 2D model, than a refined 2D
Kurutzné Kovács, Márta, Tornyos, A.
core
Importance of Schottky barriers for wide-bandgap thermoelectric devices
, 2018 The development of thermoelectric devices faces not only the challenge of optimizing the Seebeck coefficient, the electrical and thermal conductivity of the active material, but also further bottlenecks when going from the thermoelectric material to an ...
Battiato, Marco +2 more
core +1 more source
Efficient maintenance of materialized mediated views
ACM SIGMOD Record, 1995 Integrating data and knowledge from multiple heterogeneous sources -- like databases, knowledge bases or specific software packages -- is often required for answering certain queries. Recently, a powerful framework for defining mediated views spanning multiple knowledge bases by a set of constrained rules was proposed [24, 4, 16].
Lu, James +3 more
openaire +4 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source