Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling
Advanced Science, EarlyView.Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu +20 more
wiley +1 more source
[Anxiety level and physiological response to invasive dental treatments. a longitudinal study]. [PDF]
Rev Cient Odontol (Lima), 2023 Arellano-Cabezas FJ +1 more
europepmc +1 more source
Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling
Advanced Science, EarlyView.Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang +17 more
wiley +1 more source
Acta Odontológica Colombiana, 2018 ntroduction: The thermocured acrylic resins are used as base material for teeth due to their aesthetic look, low water retention and solubility, relatively low toxicity, their repairability and their simple processing technique.
Claudia Patricia Lema Soto +2 more
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Multimodal Layer‐Crossing Interrogation of Brain Circuits Enabled by Microfluidic Axialtrodes
Advanced Science, EarlyView.The study introduces a flexible microfluidic axialtrode that integrates optical, electrical, and chemical modalities within a single polymer fiber. By redistributing electrodes and fluidic channels along the fiber axis via angled cleaving, it enables simultaneous optogenetic stimulation, electrophysiological recording, and drug delivery across brain ...
Kunyang Sui +8 more
wiley +1 more source
Correction: Castro et al. Synthesis, Characterization, and Optimization Studies of Polycaprolactone/Polylactic Acid/Titanium Dioxide Nanoparticle/Orange Essential Oil Membranes for Biomedical Applications. <i>Polymers</i> 2023, <i>15</i>, 135. [PDF]
Polymers (Basel)Castro JI +7 more
europepmc +1 more source
Advanced Science, EarlyView.Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin +10 more
wiley +1 more source
Synthesis and Characterization of Ibuprofen-TiO2 Functionalized PCL Biomembranes as Candidate Materials for Wound Dressing Applications. [PDF]
Bioengineering (Basel)Vergara-Lope Nuñez JA +6 more
europepmc +1 more source
H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety
Advanced Science, EarlyView.Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou +12 more
wiley +1 more source
[Flexural Strength of Resinous Cements: In Vitro Evaluation]. [PDF]
Rev Cient Odontol (Lima)Noa-Yarasca S, López-Flores A.
europepmc +1 more source