Results 121 to 130 of about 220,118 (300)
Understanding Causation in Private Securities Lawsuits: Building on Amgen [PDF]
, 2013 With Amgen, the Supreme Court’s majority once again holds that inquiry into the alleged market impact of a misrepresentation is not required to invoke fraud on the market approach to causation so that the class can be certified.
Cox, James D.
core +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The Advancement of New Theology Using New Science: The Three Key Concepts of Thomas Torrance [PDF]
, 2012 The author begins with a selective outline of historical understandings of the concepts of space and time, in order to demonstrate their import for and engagement with theology.
Murtha-Smith, Susan
core +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Towards an Archaeology of the Contemporary Past [PDF]
, 2002 Archaeology, defined as the study of material culture, extends from the first preserved human artefacts up to the present day, and in recent years the ‘Archaeology of the Present’ has become a particular focus of research.
Buchli, V
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Judgment Day for Fraud-on-the-Market: Reflections on \u3ci\u3eAmgen\u3c/i\u3e and the Second Coming of \u3ci\u3eHalliburton\u3c/i\u3e [PDF]
, 2013 The Supreme Court has reaffirmed the fraud on the market presumption of reliance, facilitating large scale class actions for this kind of securities fraud.
Langevoort, Donald C
core +2 more sources
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Social and environmental narrative reporting : analysts' perceptions [PDF]
, 2013 An ACCA research report, Narrative Reporting: Analysts' Perceptions of its Value and Relevance was published in November 2008. The research considered analysts' views on five key elements of narrative reporting, including social and environmental ...
Campbell, David, Slack, Richard
core