Results 71 to 80 of about 220,118 (300)

The emptiness of this stage signifies nothing: the material as sign in modern theatre [PDF]

, 2007
Analysing the materiality of theatre, Cormac Power uses Brecht to analyse the modernist idealisation of the (supposedly) direct perceptual relationship between audience the material immanence of the actors onstage.
Power, Cormac
core  

The Truth-On-The-Market Defense and its Relevance in SEC Enforcement Actions [PDF]

, 2014
In this paper we describe an approach for information system design that aims at constructing the social reality in which the system is used. Thus, rather than designing the information system in a given context, the design target is the context itself ...
Chang, Lucy
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Performing weight change : a performative reading of reality-making through a relationship of meaning and doing : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in English at Massey University [PDF]

, 2009
Reading the reality-making processes that create bodies in weight change performances challenges us to understand the relationships between meanings and actions, or between discourses and materiality. This study uses a performative model to elaborate how
Caseley, Allyson June
core  

Negotiating the inhuman: Bakhtin, materiality and the instrumentalization of climate change [PDF]

, 2013
The article argues that the work of literary theorist Mikhail M. Bakhtin presents a starting point for thinking about the instrumentalization of climate change.
Adam B., Adorno T.W., Arendt H., Artaud A., Bakhtin M.M., Bakhtin M.M., Bakhtin M.M., Bakhtin M.M., Bataille G., Beck U., Chown M., Clark K., Clark N., Dalby S., Debray R., Hetherington K., Holquist M., Jonas H., Kirby V., Klein N., Levinas E., Lovelock J., McGuire B., Morson G.S., Serres M., Serres M., Shepherd D., Shklovsky V., Spivak G.C., Stallybrass P., Van Wyck P.C., Žižek S.   +31 more
core   +1 more source

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source