The Influence of Thermal and Mechanical Aging on the Flexural Properties of Conventional and 3D-Printed Materials Used in Occlusal Splints Manufacturing. [PDF]
Smardz J +6 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Author Correction: An autonomous laboratory for the accelerated synthesis of inorganic materials. [PDF]
Szymanski NJ +15 more
europepmc +1 more source
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Modeling thermoelectric performance of p-type Cu3SbSe4-based chalcogenide materials using decision trees and structural risk error minimization intelligent computational methods. [PDF]
Alharbi FS.
europepmc +1 more source
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Shear Bond Strength of Additively and Subtractively Manufactured CAD/CAM Restorative Materials After Different Surface Treatments and Adhesive Strategies: An In Vitro Study. [PDF]
Yavuz SA +4 more
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Food Packaging Materials for One-Dose Packaging for Enhanced Stability of Hygroscopic Medications. [PDF]
Yoshida T +6 more
europepmc +1 more source

