Results 121 to 130 of about 1,080,173 (282)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Microstructural Evolution of Antarctic Ice with the Rising Atmospheric CO₂: A Longitudinal Meta-Analysis

Quaternary
Antarctica, largely free from geopolitical borders, serves as a critical site for scientific research, environmental monitoring and climate studies. The continent’s ice cap holds over 60% of the Earth’s freshwater and provides a stable climatological ...
Vuk Uskoković
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Controlling Triboelectric Charge of MOFs by Leveraging Ligands Chemistry

Advanced Science
Metal–organic frameworks (MOFs) have emerged as promising materials for triboelectric nanogenerators (TENGs), but the effects of ligand choice on triboelectric charge remain underexplored.
Muhammad Noman, Qazi Muhammad Saqib, Shahid Ameen, Swapnil R. Patil, Chandrashekhar S. Patil, Jungmin Kim, Youngbin Ko, BongSoo Kim, Jinho Bae   +8 more
doaj   +1 more source

The 1,5-Benzodiazepin-2-Ones: A Review on Synthetic Strategies, Reactivity and Functional Applications

Molecules
1,5-Benzodiazepin-2-one is a significant class of heterocyclic compounds that have attracted considerable attention due to these versatile scaffolds and their multifunctional properties.
Hasan Mtiraou, Ameni Ghabi, Hanan Al-Ghulikah, Mezna Saleh Altowyan   +3 more
doaj   +1 more source

ESTUDIO DE SENSIBILIDAD Y CRECIMIENTO DE NANOESTRUCTURAS BAJO LOS POTENCIALES DE MORSE Y LENNARD JONES

Avances en Ciencias e Ingeniería, 2023
The description of the geometric changes when adding or removing a particle to the small optimal nanostructures, under the so-called good pairwise potentials is an open problem and difficult to solve. This paper presents a novel sensitivity and automatic
Carlos Barrón-Romero
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

High temperature materials chemistry Proceedings. Pt. 1 [PDF]

, 2000
Major topics of the HTMC X were: Gas phase chemistry, molecules, clusters, and vaporisation, Interface processes (e.g. corrosion, oxidation), Synthesis of advanced high temperature bulk materials, composites, and coatings, Thermodynamic and kinetic ...
Hilpert, K., Singheiser, L. (eds.), Froben, F.W., Forschungszentrum Juelich GmbH (Germany). Inst. fuer Werkstoffe und Verfahren der Energietechnik   +3 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source