Results 181 to 190 of about 10,301,594 (374)

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

open access: yesMolecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi   +5 more
wiley   +1 more source

Synthesis and characterization of DGEBA composites reinforced with Cu/Ag modified carbon nanotubes

open access: yesHeliyon, 2019
Carbon nanotubes (CNTs) are among the strongest and stiffest contender to be used as filler to elevate the properties of epoxy. The aim of this research work is to evaluate the structural, thermal, and morphological properties of multiwalled carbon ...
Anila Iqbal   +4 more
doaj  

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

open access: yesMolecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric   +11 more
wiley   +1 more source

Easily synthesized carbon dots for determination of mercury(II) in water samples

open access: yesHeliyon, 2019
In this work, a simple thermal method was used to synthesize carbon dots from citric acid and glycine precursors. It was found that Hg(II) ions can selectively quench the fluorescence emission of these carbon dots. Subsequently, a sensor was designed and
Ehsan Yahyazadeh, Farzaneh Shemirani
doaj  

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

open access: yesMolecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen   +17 more
wiley   +1 more source

A kinetic study on the degradation and biodegradability of silver nanoparticles catalyzed Methyl Orange and textile effluents

open access: yesHeliyon, 2019
The present study includes the Azadirachta indica (neem) induced Silver nanoparticles (AgNPs) by green synthesis as reducing and capping agent. Synthesized AgNPs were characterized by different instrumental techniques such as XRD (X-ray Diffraction), SEM
Niharika Nagar, Vijay Devra
doaj  

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