Results 231 to 240 of about 11,982,521 (367)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Supplementary material to "An adaptive method for speeding up the numerical integration of chemical mechanisms in atmospheric chemistry models: application to GEOS-Chem version 12.0.0"

, 2019
Lu Shen, Daniel J. Jacob, Mauricio Santillana, Xuan Wang, Wei Chen   +4 more
openalex   +1 more source

Supplementary material to "A Machine Learning Methodology for the Generation of a Parameterization of the Hydroxyl Radical: a Tool to Improve Computational-Efficiency in Chemistry Climate Models"

, 2022
Daniel C. Anderson, Melanie B. Follette‐Cook, Sarah A. Strode, Julie M. Nicely, Junhua Liu, Peter D. Ivatt, B. N. Duncan   +6 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Triptycene-like naphthopleiadene as a readily accessible scaffold for supramolecular and materials chemistry. [PDF]

Chem Sci
Amin MK, Ye C, Pang S, Liu Y, Taylor D, Nichol GS, McKeown NB.   +6 more
europepmc   +1 more source

Supplementary material to "A kinetic chemistry tagging technique and its application to modelling the stable isotopic composition of atmospheric trace gases"

, 2010
Sergey Gromov, Patrick Jöckel, R. Sander, C. A. M. Brenninkmeijer   +3 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Machine learning descriptors in materials chemistry used in multiple experimentally validated studies: Oliynyk elemental property dataset. [PDF]

Data Brief
Lee S, Chen C, Garcia G, Oliynyk A.
europepmc   +1 more source

Materials chemistry and the futurist eco-friendly applications of nanocellulose: Status and prospect

Journal of Saudi Chemical Society, 2018
Raghvendra Kumar Mishra, Arjun Sabu, S. Tiwari   +2 more
semanticscholar   +1 more source