Results 111 to 120 of about 366,410 (233)

Soft Matter: A Tale of Eco-Friendly Materials, Self-Organised Phases and Biological Impact. [PDF]

Materials (Basel)
Dierking I.
europepmc   +1 more source

Organic Structure-Directing Agent-Free Synthesis of Mordenite-Type Zeolites Driven by Al-Rich Amorphous Aluminosilicates

ACS Omega, 2021
Ting Xiao, Mizuho Yabushita, Toshiki Nishitoba, Ryota Osuga, Motohiro Yoshida, Masaki Matsubara, Sachiko Maki, Kiyoshi Kanie, Toshiyuki Yokoi, Wenbin Cao, Atsushi Muramatsu   +10 more
doaj   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Antifungal Activity of Conjugated Metal Organic Frameworks: A Multidisciplinary Undergraduate Laboratory Experiment. [PDF]

J Chem Educ
Skorjanc T, Gaber S, Bergant Marušič M, Shetty D, Valant M.   +4 more
europepmc   +1 more source

In Situ Study of Molecular Doping of Chlorine on MoS2 Field Effect Transistor Device in Ultrahigh Vacuum Conditions

ACS Omega, 2020
Nguyen Tat Trung, Mohammad Ikram Hossain, Md Iftekharul Alam, Atsushi Ando, Osamu Kitakami, Nobuaki Kikuchi, Tsuyoshi Takaoka, Yasuyuki Sainoo, Ryuichi Arafune, Tadahiro Komeda   +9 more
doaj   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Global research on the crosstalk between microbiota - intratumoral microorganisms and liver cancer: a visualization analysis. [PDF]

Infect Agent Cancer
Jiang H, Cui Y, Lei J.
europepmc   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

Sensing Techniques in Virtual Reality for Human Interaction: A Bibliometric Analysis. [PDF]

Sensors (Basel)
Del Bosque A, Fernández-Arias P, Vergara D.   +2 more
europepmc   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source