Results 131 to 140 of about 2,991,854 (304)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Retracted: Effects of Polypropylene Waste Addition as Coarse Aggregates in Concrete: Experimental Characterization and Statistical Analysis

Advances in Materials Science and Engineering
Advances in Materials Science and Engineering
doaj   +1 more source

Retracted: Molecular Dynamics Simulation Calculation Method for Elasticity and Plasticity of Metal Nanostructures

Advances in Materials Science and Engineering, 2023
Advances in Materials Science and Engineering
doaj   +1 more source

Molecular Diversity of Lupane Hybrids in Drug Design and Materials Science. [PDF]

Molecules
Lipson VV, Shirobokova MG, Gümüş MK, Ozturkcan A, Chebanov VA.   +4 more
europepmc   +1 more source

MATERIALS SCIENCE [PDF]

Chemical & Engineering News Archive, 2002
openaire   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Retracted: Optimizing the Characteristics of the Laser Hardfacing Process Parameters to Maximize the Wear Resistance of Ni-Based Hard-Faced Deposits Using the RSM Technique

Advances in Materials Science and Engineering
Advances in Materials Science and Engineering
doaj   +1 more source

Retracted: Fabrication of Hollow Needle Tips with Nanoholes by Plasma Maskless Processing and Calculation and Detection of Complex Surface Edges

Advances in Materials Science and Engineering, 2023
Advances in Materials Science and Engineering
doaj   +1 more source

Biomineralization-Driven Advances in Materials Science and Biomedical Engineering. [PDF]

JACS Au
Guo J, Gao F, Zhang F, Zhao X, Zhao R.
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source