Results 291 to 300 of about 19,473,068 (392)

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

An Up-to-Date Review of Materials Science Advances in Bone Grafting for Oral and Maxillofacial Pathology. [PDF]

Materials (Basel)
Nicolae CL, Pîrvulescu DC, Niculescu AG, Epistatu D, Mihaiescu DE, Antohi AM, Grumezescu AM, Croitoru GA.   +7 more
europepmc   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Applying the Techniques of Materials Science towards an Understanding of the Process of Canine Intervertebral Disc Degeneration. [PDF]

Animals (Basel)
Rojas V, Jugdaohsingh R, Rayment A, Brown A, Fenn J, Crowley J, Lovric V, Powell J, Freeman P.   +8 more
europepmc   +1 more source

Synchrotron radiation for materials science research.

, 1987
Hiroshi Iwasaki
openalex   +2 more sources

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Importance of powder diffraction raw data archival in a curated database for materials science applications. [PDF]

Acta Crystallogr B Struct Sci Cryst Eng Mater
Kabekkodu S, Blanton T.
europepmc   +1 more source

Materials & Methods for Political Science Research (Book Review)

, 1980
Roy H. Fry
openalex   +2 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Resolving Structures of Paramagnetic Systems in Chemistry and Materials Science by Solid-State NMR: The Revolving Power of Ultra-Fast MAS. [PDF]

Angew Chem Int Ed Engl
Koppe J, Sanders KJ, Robinson TC, Lejeune AL, Proriol D, Wegner S, Purea A, Engelke F, Clément RJ, Grey CP, Pell AJ, Pintacuda G.   +11 more
europepmc   +1 more source