Results 91 to 100 of about 1,110,649 (259)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Science and Engineering of Composite Materials
In view of the rapid growth of the science and technology of composite materials, there is a need for published documentation on their structure, properties, and the integration of structure-property relations with processing, design and fabrication ...
Michele Bacciocchi
core +3 more sources
Retracted: Nanoscale Characterization and Impurities of Fused Silica Optical Surfaces
Advances in Materials Science and Engineering, 2023 Advances in Materials Science and Engineering
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Retracted: Simulation Analysis of External Damage and Repair of the Gas Transmission Pipeline
Advances in Materials Science and Engineering, 2023 Advances in Materials Science and Engineering
doaj +1 more source
, 2019 Dielectric materials are greatly desired for electromagnetic absorption applications. Lots of research shows that conduction loss and polarization are two of the most important factors determining complex permittivity.
Guangbin Ji +17 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Advances in Materials Science and Engineering, 2023 Advances in Materials Science and Engineering
doaj +1 more source
Search, reuse and sharing of research data in materials science and engineering-A qualitative interview study. [PDF]
PLoS One, 2020 Suhr B, Dungl J, Stocker A.
europepmc +1 more source