Results 81 to 90 of about 3,168,754 (306)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Synthesis of Magnetic Materials Pseudobrookite Fe2tio5 From Local Resources of Mineral [PDF]

, 2013
The synthesis and characterization of magnetic materials pseudobrookite Fe2TiO5 from local resources of iron sand has been performed. Iron sand mineral is obtained from the coast of Banten.
Adi, W. A. (Wisnu), Sardjono, P. (Prijo), Sudirman, S. (Sudirman)   +2 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Chemical modification of poly(p-phenylene) for use in ablative compositions [PDF]

, 1972
Development of ablative materials based on modification of polyphenylene compounds is discussed. Chemical and physical properties are analyzed for application as heat resistant materials. Synthesis of linear polyphenylenes is described.
Hammermesh, C. L., Heimbuch, A. H., Parker, J. A., Vincent, D. N.   +3 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Synthesis of atomically layered and chemically ordered rare-earth (RE) i-MAX phases; (Mo2/3RE1/3)2GaC with RE = Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu

Materials Research Letters, 2019
We report the synthesis of eight new members of the i-MAX family, of the formula (Mo2/3RE1/3)2GaC, where RE = Gd, Tb, Dy, Ho, Er, Tm, Lu, and Yb, the latter not previously incorporated in a MAX phase.
Andrejs Petruhins, Jun Lu, Lars Hultman, Johanna Rosen   +3 more
doaj   +1 more source

Fine-scale analysis of biomineralized mollusc teeth using FIB and TEM [PDF]

, 2010
When it comes to mineral synthesis, there is a lot we can learn from nature. Although we can synthesize a range of materials in the laboratory, the experimental conditions are often constrained to particular ranges of temperature, pH, etc.
Clode, P.L., Kong, C., Macey, D.J., Saunders, M., Shaw, J.A.   +4 more
core   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Bicontinuous RuO2 nanoreactors for acidic water oxidation

Nature Communications
Improving activity and stability of Ruthenium (Ru)-based catalysts in acidic environments is eager to replace more expensive Iridium (Ir)-based materials as practical anode catalyst for proton-exchange membrane water electrolyzers (PEMWEs).
Ding Chen, Ruohan Yu, Kesong Yu, Ruihu Lu, Hongyu Zhao, Jixiang Jiao, Youtao Yao, Jiawei Zhu, Jinsong Wu, Shichun Mu   +9 more
doaj   +1 more source

A Cu2+ (S = 1/2) Kagom\'e Antiferromagnet: MgxCu4-x(OH)6Cl2 [PDF]

, 2010
Spin-frustrated systems are one avenue for inducing macroscopic quantum states in materials. However, experimental realization of this goal has been difficult because of the lack of simple materials and, if available, the separation of the unusual ...
Anderson P. W., Braithwaite R. S. W., Collins M. F., Daniel G. Nocera, Danna E. Freedman, de Vries M. A., Greedan J. E., Hamilton W. C., Helton J. S., Lee S. H., McQueen T. M., Moessner R., Peter Müller, Ramirez A. P., Robin Chisnell, Shaoyan Chu, Shores M. P., Tyrel M. McQueen, Young S. Lee, Zheng X. G.   +19 more
core   +1 more source