Results 111 to 120 of about 4,033,138 (351)
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
MetalsHydrogen embrittlement (HE) poses the risk of premature failure for many metals, especially high-strength steels. Due to the utilization of hydrogen as an environmentally friendly energy source, efforts are made to improve the resistance to HE at ...
Jens Jürgensen +4 more
doaj +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
High-Pressure Oxygen Test Evaluations [PDF]
The relevance of impact sensitivity testing to the development of the space shuttle main engine is discussed in the light of the special requirements for the engine.
Key, C. F., Schwinghamer, R. J.
core +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Materials testing of the IUS techroll seal material [PDF]
As a part of the investigation of the control system failure Inertial Upper Stage on IUS-1 flight to position a Tracking and Data Relay Satellite (TDRS) in geosynchronous orbit, the materials utilized in the techroll seal are evaluated for possible ...
Hall, W. B., Nichols, R. L.
core +1 more source
Nondestructive testing using ultrasonic sensor [PDF]
, 2016 Nondestructive testing (NDT) is the process of inspection or evaluating materials or component without destroying the functionality, serviceability and the structure of the testing product.
Abd Rahman, Muhamad Umar Faruq +3 more
core
Effect of Nonparallel End Face on Energy Dissipation Analyses of Rocklike Materials Based on SHPB Tests [PDF]
, 2019 Pu Yuan, Ning-Ning Wei, Qinyong Ma
openalex +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Local lattice distortions and chemical short-range order in MoNbTaW
Materials Research LettersExtended X-ray absorption fine structure (EXAFS) conducted on an equiatomic MoNbTaW bcc medium-entropy alloy that was annealed at 2273 K reveals unexpectedly small 1st and 2nd shell element-specific lattice distortions.
Andrea Fantin +4 more
doaj +1 more source