Results 111 to 120 of about 1,642,260 (307)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

X-ray non-destructive testing – an essential tool during modern aeronautics material technology design and development

, 2019
О. Г. Оспенникова, Е. И. Косарина, О. А. Крупнина   +2 more
openalex   +1 more source

Patientennahe Laboratoriumsdiagnostik (Point-of-Care-Testing): Empfehlungen zum Einsatz von unterschiedlichem Probenmaterial für die Diagnostik des Diabetes mellitus / Bedside testing in laboratory diagnostics (point-of-care testing): recommendations for the use of different testing materials in the diagnostics of Diabetes mellitus [PDF]

, 2004
Rainer Haeckel, Petra Hänecke, Theodor Koschinsky, Peter B. Luppa, H. Schlebusch, Hans Günther Wahl   +5 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Development of Analytical Reference Material for Proficiency Test of Pesticide Multi-residue Analysis in Tomato [PDF]

, 2016
Jong-Hwan Kim, Young-Gon Oh, Sung-Gil Choi, Su‐Myeong Hong, Sun-bae Kim, In-Duk Woo, Junyoung Kim, Jong‐Su Seo   +7 more
openalex   +1 more source

Supplementary Material for: Management of Germ Cell Tumours of the Testes in Adult Patients: German Clinical Practice Guideline, PART II – Recommendations for the Treatment of Advanced, Recurrent, and Refractory Disease and Extragonadal and Sex Cord/Stromal Tumours and for the Management of Follow-Up, Toxicity, Quality of Life, Palliative Care, and Supportive Therapy

, 2021
Sabine Kliesch, Stefanie Schmidt, Doris Wilborn, Clemens Aigner, W. Albrecht, Jens Bedke, Matthias Beintker, Dirk Beyersdorff, Carsten Bokemeyer, Jonas Busch, Joseph Claßen, Marjolein deWit, Klaus‐Peter Dieckmann, Thorsten Diemer, Annette Dieing, Matthias Göckel, B. Göckel-Beining, Oliver W. Hakenberg, Axel Heidenreich, Julia Heinzelbecker, Kathleen Herkommer, Thomas Hermanns, S. Kaufmann, Marko Kornmann, J. Kotzerke, S. Krege, G. Kristiansen, Anja Lorch, Arndt‐Christian Müller, Karin Oechsle, Timur Ohloff, Christoph Oing, U. Otto, David Pfister, Renate Pichler, Heinrich Recken, Oliver Rick, Yvonne Rudolph, Christian Ruf, J. Schirren, H. Schmelz, Heinz Schmidberger, M. Schrader, Stefan Schweyer, Stefanie Seeling, Rainer Souchon, Christian Winter, Ch. Wittekind, Friedemann Zengerling, Dirk‐Henrik Zermann, Roger Zillmann, Peter Albers   +51 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Supplementary Material for: Instrumented Functional Test for Objective Outcome Evaluation of Balance Rehabilitation in Elderly Fallers: A Clinical Study

, 2022
Alireza Noamani, Vette A.H., Hossein Rouhani   +2 more
openalex   +1 more source