Results 131 to 140 of about 2,787,926 (407)
Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen
Advanced Science, EarlyView.Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.Xiong Wang, Qing Wu, Hao‐Long Zeng, Yin Shen, Hong‐Han Zhang, Jun Gong, Qi Zhang, Jia‐Zhao Xie, Da‐Wei Ye, Zi‐Yong Sun, Zhong‐Chun Liu, Li‐Ming Cheng, Di Li +12 morewiley +1 more sourceExclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring
Advanced Science, EarlyView.Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li +13 morewiley +1 more sourceThe impact of HIV exposure and maternal Mycobacterium tuberculosis infection on infant immune responses to bacille Calmette-Guérin vaccination. [PDF]
, 2015 OBJECTIVE: The objective of this study is to assess the effect of maternal HIV and Mycobacterium tuberculosis (Mtb) infection on cellular responses to bacille Calmette-Guérin (BCG) immunization.
DESIGN: A mother-infant cohort study.Adegnika, Borges-Almeida, Brahmbhatt, Chougnet, Clerici, Combadiere, Cotton, Dauby, Economides, Elliott, Elrefaei, Embree, Epalza, Hanekom, Jones, Kampmann, Kemp, Koyanagi, Kuhn, Madhi, Malhotra, Malhotra, Mansoor, Marinda, Mazzola, McNally, Miles, Nakiyingi, Newell, Nielsen, Ono, Otieno, Puissant-Lubrano, Rahman, Resino, Rich, Roederer, Scholzen, Schramm, Schramm, Shapiro, Soares, Torre, Van Rie, Velilla, Weir +45 morecore +2 more sourcesMaternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Nature Genetics, 2018 Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes.N. Warrington, R. Beaumont, M. Horikoshi, F. Day, Ø. Helgeland, Ø. Helgeland, Ø. Helgeland, Charles Laurin, Charles Laurin, J. Bacelis, Shouneng Peng, K. Hao, B. Feenstra, A. Wood, A. Mahajan, Jessica Tyrrell, Jessica Tyrrell, N. Robertson, N. W. Rayner, Zhen Qiao, G. Moen, G. Moen, M. Vaudel, C. Marsit, Jia Chen, M. Nodzenski, T. Schnurr, M. Zafarmand, J. Bradfield, N. Grarup, Marjolein N. Kooijman, R. Li-Gao, F. Geller, T. Ahluwalia, L. Paternoster, R. Rueedi, R. Rueedi, V. Huikari, J. Hottenga, L. Lyytikäinen, A. Cavadino, A. Cavadino, S. Metrustry, D. Cousminer, D. Cousminer, Ying Wu, E. Thiering, Carol A. Wang, C. Have, N. Vilor-Tejedor, Peter K. Joshi, J. Painter, I. Ntalla, Ronny Myhre, N. Pitkänen, E. M. Leeuwen, R. Joro, V. Lagou, V. Lagou, R. Richmond, R. Richmond, Ana Espinosa, S. Barton, Hazel M. Inskip, Hazel M. Inskip, J. Holloway, L. Santa-Marina, X. Estivill, W. Ang, J. Marsh, C. Reichetzeder, L. Marullo, B. Hocher, K. Lunetta, J. Murabito, C. Relton, C. Relton, M. Kogevinas, L. Chatzi, Catherine Allard, Luigi Bouchard, Luigi Bouchard, M. Hivert, M. Hivert, Ge Zhang, Ge Zhang, Louis J. Muglia, Louis J. Muglia, Jani Heikkinen, C. S. Morgen, A. H. C. V. Kampen, A. H. C. V. Kampen, Barbera D. C. Schaik, F. Mentch, C. Langenberg, J. Luan, R. Scott, Jing Hua Zhao, G. Hemani, G. Hemani, Susan M. Ring, Susan M. Ring, A. Bennett, K. Gaulton, K. Gaulton, J. Fernández-Tajes, N. Zuydam, C. Medina-Gomez, H. G. D. Haan, F. Rosendaal, Zoltán Kutalik, Zoltán Kutalik, P. Marques-Vidal, Shikta Das, G. Willemsen, H. Mbarek, M. Müller-Nurasyid, M. Standl, E. V. Appel, C. Fonvig, C. Trier, Catharina E. M. van Beijsterveldt, Mario Murcia, Mario Murcia, Mariona Bustamante, Mariona Bustamante, S. Bonàs-Guarch, D. Hougaard, J. Mercader, J. Mercader, J. Mercader, A. Linneberg, Katharina E. Schraut, P. Lind, S. Medland, B. Shields, B. Knight, Jin-Fang Chai, K. Panoutsopoulou, M. Bartels, Friman Sánchez, J. Stokholm, D. Torrents, R. Vinding, Sara M. Willems, M. Atalay, B. Chawes, P. Kovacs, I. Prokopenko, I. Prokopenko, M. Tuke, H. Yaghootkar, K. Ruth, Samuel E. Jones, Po-Ru Loh, Po-Ru Loh, A. Murray, M. Weedon, A. Tönjes, M. Stumvoll, K. Michaelsen, Aino-Maija Eloranta, T. Lakka, C. Duijn, W. Kiess, A. Körner, H. Niinikoski, H. Niinikoski, K. Pahkala, Olli T Raitakari, Olli T Raitakari, B. Jacobsson, B. Jacobsson, E. Zeggini, G. Dedoussis, Y. Teo, S. Saw, G. Montgomery, H. Campbell, James F. Wilson, T. Vrijkotte, Martine Vrijheid, Martine Vrijheid, E. D. Geus, M. Hayes, H. Kadarmideen, J. Holm, L. Beilin, C. Pennell, Joachim Heinrich, L. Adair, J. Borja, K. Mohlke, Johan G. Eriksson, Johan G. Eriksson, E. Widén, A. Hattersley, A. Hattersley, T. Spector, M. Kähönen, J. Viikari, J. Viikari, T. Lehtimäki, D. Boomsma, S. Sebert, P. Vollenweider, T. I. Sørensen, T. I. Sørensen, H. Bisgaard, K. Bønnelykke, J. Murray, M. Melbye, E. Nøhr, D. Mook-Kanamori, F. Rivadeneira, A. Hofman, J. Felix, V. Jaddoe, T. Hansen, C. Pisinger, A. Vaag, O. Pedersen, A. Uitterlinden, M. Järvelin, C. Power, Elina Hyppönen, Elina Hyppönen, D. Scholtens, W. Lowe, George Davey Smith, George Davey Smith, N. Timpson, N. Timpson, Andrew P. Morris, Andrew P. Morris, Andrew P. Morris, N. Wareham, H. Hakonarson, H. Hakonarson, S. Grant, T. Frayling, Debbie A. Lawlor, Debbie A. Lawlor, P. R. Njølstad, P. R. Njølstad, Stefan Johansson, Stefan Johansson, K. Ong, Mark I. McCarthy, Mark I. McCarthy, J. Perry, D. Evans, D. Evans, D. Evans, R. Freathy, R. Freathy +255 moresemanticscholar +1 more sourceDecoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth
Advanced Science, EarlyView.Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng +12 morewiley +1 more sourceHRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis
Advanced Science, EarlyView.This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang +10 morewiley +1 more source
