Results 221 to 230 of about 10,926,372 (352)

Fetomaternal Outcome Among Antenatal Attendees With Advanced Maternal Age: A Cohort Study. [PDF]

Cureus
Toufique H, Bano S, Shaikh AS, Rafique S, Rafique L, Zishan I.   +5 more
europepmc   +1 more source

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

Advanced maternal age at first delivery and long-term maternal risk for endocrine morbidity. [PDF]

Arch Gynecol Obstet
Rotem O, Steiner N, Sheiner E, Wainstock T, Sergienko R, Kessous R.   +5 more
europepmc   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Maternal and perinatal outcomes in adolescents and women with advanced maternal age. [PDF]

Rev Saude Publica
Gama SGND, Schilithz AOC, Leal MDC, Carmo TTD, Theme-Filha MM, Barros DC, Soares GCF, Martinelli KG.   +7 more
europepmc   +1 more source

Clotrimazole‐loaded PLGA microparticles for local drug delivery to the vagina: Shape does matter

Animal Models and Experimental Medicine, EarlyView.
Clotrimazole‐loaded PLGA microparticles for intravaginal delivery. Abstract Background Intravaginal drug administration is the most promising strategy for treating vaginal infections to protect women's health, such as vulvovaginal candidiasis (VVC). However, conventional vaginal formulations in the clinic face challenges such as drug leakage and low ...
Yanyu Li, Jingting Luo, Shitao Zou, Xin Zhang, Zhen Wang, Ziwen Jiang, Jingjie Wang, Zhaoxia Liu, Zhimin Zhou   +8 more
wiley   +1 more source

Aging mothers, failing placentas? Association between maternal age and placental perfusion in a low-resource setting. [PDF]

PLOS Glob Public Health
Eze IO, Nwagha UI, Eze SC, Abdul AE, Igboezue VC, Muhammed R.   +5 more
europepmc   +1 more source

The Dynamics of Neurofilament Light Chain in Spinal Muscular Atrophy

Annals of Neurology, EarlyView.
Objective Newborn screening (NBS) for spinal muscular atrophy (SMA) facilitates early diagnosis and treatment for affected individuals. However, fluid biomarkers that provide early insights into disease activity and outcomes in a neonatal cohort and those unable to access (due to reimbursement criteria) or deferring immediate treatment are lacking ...
Arlene D'Silva, Karen Herbert, Lakshmi Balaji, Jia Mei He, Tejaswi Kandula, Hugo A. Sampaio, Hooi‐Ling Teoh, Esther Tantsis, Jihee Sohn, Nancy Briggs, Nickson Ning, Matthew C. Kiernan, Didu S. Kariyawasam, Michelle A. Farrar   +13 more
wiley   +1 more source

Prediction of Pregnancy-Related Complications in Women of Advanced Maternal Age: A Nomogram Based on LASSO and Logistic Regression. [PDF]

Int J Womens Health
Guo F, Fang H, Sun Z, Huo G, Cui Y.
europepmc   +1 more source

Delayed motherhood: Birth outcomes at extremely advanced maternal age: A retrospective cohort study. [PDF]

Medicine (Baltimore)
Karabulut A, Kantarci S, Kantarci S, Dağli U, Atici E, İleri A, Engür D, Engür D, Uygur Ö, Karataşli V.   +9 more
europepmc   +1 more source