Results 81 to 90 of about 793,157 (300)

Are Maternal and Child Care Programs Reaching the Poorest Regions in the Philippines? [PDF]

, 2008
While the national average for maternal and child health services utilization shows improvement, the Philippines is yet to achieve the MDG targets for maternal and child health.
Lagrada, Leizel P., Lavado, Rouselle F.
core  

Accelerating Maternal and Child Health Gains in Papua New Guinea [PDF]

, 2015
Many priority countries in the countdown to the millennium development goals deadline are lagging in progress towards maternal and child health (MCH) targets. Papua New Guinea (PNG) is one such country beset by challenges of geographical inaccessibility,
Byrne, Abbey, Hodge, Andrew, Jimenez-Soto, Eliana   +2 more
core   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Two novel KCNA1 variants identified in two unrelated Chinese families affected by episodic ataxia type 1 and neurodevelopmental disorders

Molecular Genetics & Genomic Medicine, 2020
Background Pathogenic KCNA1 variants have been linked to episodic ataxia type 1 (EA1), a rare neurological syndrome characterized by continuous myokymia and attacks of generalized ataxia that can be triggered by fever, abrupt movements, emotional stress,
Haiming Yuan, Huihua Yuan, Qingming Wang, Wanhua Ye, Ruixia Yao, Wanfang Xu, Yanhui Liu   +6 more
doaj   +1 more source

The Role of Maternal Cognitive Ability in Child Health [PDF]

The literature on child health suggests mother`s schooling is a key determinant of child health. Little is known of how other sources of maternal human capital contribute to her children`s health. This paper investigates the differential returns on child
Graciela Teruel, Luis Rubalcava
core  

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Analysis of human papillomavirus infection and its correlation with cervical lesions in Huizhou women

Scientific Reports
To analyze the genotype distribution of human papillomavirus (HPV) infection in women in the Huizhou region of China and determine its correlation with age and degree of cervical lesions, with the aim to understand the characteristics of HPV infection in
Xiaoting Wang, Zengrui Ju, Qifei Lai, Qiaomei Liu, Lijie Gao, Jisheng Zhong   +5 more
doaj   +1 more source

11 years of tracking aid to reproductive, maternal, newborn, and child health: estimates and analysis for 2003-13 from the Countdown to 2015. [PDF]

BACKGROUND: Tracking aid flows helps to hold donors accountable and to compare the allocation of resources in relation to health need. With the use of data reported by donors in 2015, we provided estimates of official development assistance and grants ...
Arregoces, Leonardo, Borghi, Josephine, Grollman, Christopher, Martínez-Álvarez, Melisa, Mills, Anne, Pitt, Catherine   +5 more
core   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Identification of EVC variants and the preimplantation genetic testing in a Chinese family

Frontiers in Medicine
Fetal genetic skeletal disorders are common congenital anomalies with notable genetic and phenotypic heterogeneity. Genetic analysis plays an important role in the definitive diagnosis of these skeletal conditions.
Haiyan Luo, Zhen Guo, Yao Yu, Jia Chen, Qing Lu, Yan Yang, Ting Huang, Danping Liu, Wangli Nie, Wan Lu, Bicheng Yang, Jun Zou, Yanqiu Liu, Yongyi Zou   +13 more
doaj   +1 more source