Results 81 to 90 of about 570,257 (360)

Using an adoption–biological family design to examine associations between maternal trauma, maternal depressive symptoms, and child internalizing and externalizing behaviors [PDF]

, 2017
Maternal trauma is a complex risk factor that has been linked to adverse child outcomes, yet the mechanisms underlying this association are not well understood.
Achenbach, Aleksandria Perez Grabow, Atika Khurana, Beck, Cicchetti, Cicchetti, Cole, Daniel S. Shaw, David Reiss, Gordon T. Harold, Izard, Jenae M. Neiderhiser, Jody M. Ganiban, Kellermann, Leslie D. Leve, McGuffin, McNeil, Misaki N. Natsuaki, Muthén, Sotero   +19 more
core   +1 more source

Hydrogel Confinement Strategies for 3D Cell Culture in Microfluidic Systems

Advanced Materials Technologies, EarlyView.
Hydrogel confinement structures are key to organizing 3D cell cultures in microfluidic devices. This review classifies five structural strategies (micropillar, phaseguide, porous membrane, stepped‐height, and support‐free) and examines their trade‐offs alongside fabrication methods.
Soohyun Kim, Min Seok Lee, Sung Kyun Lee
wiley   +1 more source

Effects of social hierarchy in primiparous and multiparous goats on nursing behavior during lactation

Frontiers in Ethology
IntroductionGoats are gregarious animals with a social organization differentiated by their stratification into defined social ranks. Relatively little is known about whether these social relationships affect the behavioral activity of mothers and ...
Andrea García-Cázares, Paolo Cano-Suárez, Angélica Terrazas-García   +2 more
doaj   +1 more source

Infant-mother attachment and the growth of externalizing problems across the primary-school years [PDF]

, 2011
Background:  Some contend that attachment insecurity increases risk for the development of externalizing behavior problems in children. Method:  Latent-growth curve analyses were applied to data on 1,364 children from the NICHD Study of Early Child ...
Achenbach, Ainsworth, Allison, Belsky, Belsky, Bentler, Curran, Curran, Erickson, Fearon, Kobak, Lamb, Lyons Ruth, Main, Matas, Moss, Muthén, NICHD Early Child Care Network., NICHD Early Child Care Research Network., Preacher, Renken, Rutter, Schafer, Van IJzendoorn, Vandell   +24 more
core   +1 more source

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Persistent autism-relevant behavioral phenotype and social neuropeptide alterations in female mice offspring induced by maternal transfer of PBDE congeners in the commercial mixture DE-71 [PDF]

, 2021
Elena V. Kozlova, Matthew C. Valdez, Maximillian E. Denys, Anthony E. Bishay, Julia M. Krum, K. Rabbani, Valeria Carrillo, Gwendolyn González, Gregory Lampel, Jasmin D. Tran, Brigitte M. Vazquez, Laura M. Anchondo, Syed A. Uddin, Nicole Huffman, Eduardo Monarrez, Duraan S. Olomi, Bhuvaneswari D. Chinthirla, Richard E. Hartman, Prasada Rao S. Kodavanti, Gladys Chompré, Allison L. Phillips, Heather M. Stapleton, Bernhard Henkelmann, Karl‐Werner Schramm, Margarita Currás‐Collazo   +24 more
openalex   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Socio-demographic factors influences on guardians’ perception of Developmental Coordination Disorder among Brazilian schoolchildren

Motriz: Revista de Educacao Fisica, 2018
AIM The objective of this study was to identify socio-demographic factors that are associated with the guardians’ perception of developmental coordination disorder among schoolchildren from seven to ten years old.
Jorge Lopes Cavalcante Neto, Tatiana de Oliveira Sato, Eloisa Tudella   +2 more
doaj   +1 more source