Results 171 to 180 of about 402,559 (310)

Tacrolimus exposure during pregnancy in kidney and liver transplantation recipients: A comparison between whole blood and plasma concentration‐to‐dose ratios

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tacrolimus monitoring is generally performed in whole blood (WB). Most (>85%) of circulating tacrolimus is bound to red blood cells. During pregnancy, WB monitoring might be suboptimal because of physiological changes including increased plasma volume and decreased haematocrit.
Jildau R. Meinderts, Paola Mian, Frederike G. I. van Vilsteren, Karien M. H. van de Wetering, Jelmer R. Prins, Stefan P. Berger, Daan J. Touw, Margriet F. C. de Jong   +7 more
wiley   +1 more source

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Maternal Complications and Prescription Opioid Exposure During Pregnancy: Using Marginal Structural Models. [PDF]

Drug Saf, 2021
Wen X, Wang S, Lewkowitz AK, Ward KE, Brousseau EC, Meador KJ.   +5 more
europepmc   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Patterns of antiseizure medication prescription in pregnancy and maternal complications in women with epilepsy: A retrospective study in Saudi Arabia. [PDF]

Saudi Pharm J, 2022
Alsfouk BA, Almarzouqi MR, Alageel S, Alsfouk AA, Alsemari A.   +4 more
europepmc   +1 more source

Reading hominin life history in fossil bones and teeth: methods to test hypotheses regarding its evolution

Biological Reviews, EarlyView.
ABSTRACT Human life history is derived compared to that of our closest living relatives, the great apes. It has been suggested that these derived traits are causally related to aspects of our ecology, social behaviour and cognitive abilities. However, resolving this requires that we know the evolutionary trajectory of our distinctive pattern of growth,
Paola Cerrito, Judith M. Burkart, Carel van Schaik   +2 more
wiley   +1 more source

Pregnancy Outcomes and Maternal Complications During the Second Wave of Coronavirus Disease 2019 (COVID-19) in India. [PDF]

Obstet Gynecol, 2021
Mahajan NN, Mahajan NN, Pophalkar M, Patil S, Yewale B, Chaaithanya IK, Mahale SD, Gajbhiye RK.   +7 more
europepmc   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

The Effectiveness of Modified Early Obstetric Warning System Training on Midwives' Knowledge and Interpersonal Skills for Early Detection of Maternal Complications in Indonesia. [PDF]

Iran J Nurs Midwifery Res
Nugraheny E, Ulfa Y, Allailiyah N, Kismoyo CP, Sulistyawati N, Margiyati M, Ariani T, Bartini I, Paramashanti BA, Purwatiningsih Y, Lestyoningrum SD.   +10 more
europepmc   +1 more source

Pregnancy and delivery in women receiving maintenance hemodialysis in Japan: analysis of potential risk factors for neonatal and maternal complications. [PDF]

J Nephrol, 2021
Hirano H, Ueda T, Tani H, Kosaka K, Nakatani E, Hawke P, Mori K, Mori N.   +7 more
europepmc   +1 more source