Results 141 to 150 of about 1,008,936 (253)

Unintended Pregnancies and Breastfeeding Studies during Central Nervous System Drug Development: How Are they Handled, Is There Room for Improvement?

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnant and breastfeeding individuals are routinely excluded from clinical drug development, creating persistent evidence gaps in pharmacology, safety, and dosing. Despite mandatory contraception and pregnancy testing, unintended pregnancies occur, particularly during the development of central nervous system (CNS) medicines used by women of ...
Sam Schoenmakers, Charlotte Bakker, Alexandra Ganev, Florence Butlen‐Ducuing, Corinne S. de Vries   +4 more
wiley   +1 more source

Zebrafish inversin mutants develop scoliosis in the absence of laterality defects

Developmental Dynamics, EarlyView.
Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick, Lorraine Eley, Deborah J. Henderson, Bill Chaudhry   +3 more
wiley   +1 more source

Postpartum haemorrhage - an insurmountable problem?

Case Reports in Women's Health, 2023
Lawrence Chauke, Shastra Bhoora, Nnabuike Chibuoke Ngene   +2 more
doaj   +1 more source

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

Maternal deaths in the UK before and during the COVID-19 pandemic. [PDF]

Acta Obstet Gynecol Scand
Felker A, Knight M.
europepmc   +1 more source

Mental Health and Well‐Being Across the Eating Disorder Spectrum—From Milder Symptoms of Disordered Eating Behaviors to Diagnosed Eating Disorders

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective This study examined differences in mental health and well‐being, risk behaviors, suicidality, and social functioning across a proposed eating disorder (ED) spectrum, ranging from no ED symptoms to clinically diagnosed EDs. Methods We examined 44,303 participants in the 18‐year follow‐up in the Danish National Birth Cohort (DNBC‐18 ...
Anne V. Aurup, Andrea Joensen, Else Marie Olsen, Nadia M. Mikkelsen, Stine Danielsen, Pernille Stemann Larsen, Katrine Strandberg‐Larsen   +6 more
wiley   +1 more source

The Forgotten Collateral Damage of Maternal Deaths. [PDF]

Matern Fetal Med
Hermanto TJ, Akyuni Q.
europepmc   +1 more source

Electroclinical phenotypes—genetic characterization of developmental and epileptic encephalopathies in a cohort study

Epileptic Disorders, EarlyView.
Abstract Objective Developmental and epileptic encephalopathies (DEEs) are characterized by refractory seizures and frequently recurring epileptic activity with neurodevelopmental delay or regression that usually begin in early life. We aimed to define the relationship between electroclinical features and etiology, as well as the genotype–phenotype ...
Burcu Yaman, Fulya Kurekci, Sinan Akbas, Ceyda Oney, Mehmet Akif Kilic, Hulya Maras Genc, Ayca Dilruba Aslanger, Edibe Pembegul Yildiz   +7 more
wiley   +1 more source

Understanding stillbirths and maternal deaths in Pakistan: evidence from a national household survey. [PDF]

J Glob Health
Nausheen S, Ariff S, Umer M, Qadir Z, Nooruddin S, Habib MA, Rizvi A, Khan A, Chauhadry IA, Kalter HD, Soofi SB, Black RE, Bhutta ZA.   +12 more
europepmc   +1 more source

(A) clinical study on maternal deaths and perinatal deaths at the Severance hospital : 9-year survey (February 1959-Feb. 1968)

, 1968
의학과/석사[한글] [영문] A review was made of all maternal deaths at Severance Hospital during the 9 year period from 1959 through 1968. There were 5873 live births and 70 total maternal deaths and 335 total perinatal deaths.
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