Results 71 to 80 of about 1,008,936 (253)

Effect of HIV infection on pregnancy-related mortality in sub-Saharan Africa: secondary analyses of pooled community-based data from the network for Analysing Longitudinal Population-based HIV/AIDS data on Africa (ALPHA) [PDF]

, 2013
Background Model-based estimates of the global proportions of maternal deaths that are in HIV-infected women range from 7% to 21%, and the effects of HIV on the risk of maternal death is highly uncertain.
Todd, J., Herbst, K, Byass, P., Calvert, C, Newell, ML, Lutalo, Tom,, Newell, Marie-Louise, Zaba, Basia,, Newell, Marie-Louise,, Isingo, Raphael,, Isingo, Raphael, Byass, P, Nakiyingi-Miiro, J., Herbst, K., Marston, M, Ronsmans, Carine, Ronsmans, Carine,, Marston, Milly,, Todd, Jim,, Herbst, Kobus,, Nakiyingi-Miiro, J, Robertson, Laura, Zaba, Basia, Marston, M., Calvert, C., Robertson, Laura,, Crampin, AC, Herbst, Kobus, Byass, Peter,, Crampin, Amelia,, Todd, J, Zaba, B, Calvert, Clara,, Marston, Milly, Isingo, R, Ronsmans, C, Isingo, R., Lutalo, Tom, Boerma, Ties,, Boerma, T., Todd, Jim, Crampin, Amelia, Crampin, A., Nakiyingi-Miiro, Jessica,, Lutalo, T, Boerma, Ties, Nakiyingi-Miiro, Jessica, Boerma, T, Newell, M.L., Zaba, B., Calvert, Clara, Byass, Peter, Ronsmans, C., Lutalo, T., Robertson, L., Robertson, L   +55 more
core   +1 more source

A Biomimetic cRGDyk‐Engineered Platelet Nanoplatform for ACAD11 Delivery to Trigger Pyroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao, Wei Feng, Wei Zong, Yi Li, Xinyue Qin, Xinyue Wang, Yubo Yang, Guanhua Chen, Yiting Hou, Xuan Tan, Lin Chen, Ming Zhang, Feng Wang   +12 more
wiley   +1 more source

a Main maternal condition attributed for neonatal deaths.

, 2023
b Maternal conditions identified for CHAMPS deaths that occurred in the neonatal period, by WHO ICD 10 PM underlying cause of the death for the newborn, 2016–2021.
Dickens Onyango (8195922), Dadi Marami (6081188), Toyah Els (11979248), Atique Iqbal Chowdhury (3692341), Robert F. Breiman (9117186), Beth A. Tippet-Barr (14817704), Karen L. Kotloff (7252475), Surafel Fentaw (8917601), Victor Akelo (450373), Quique Bassat (89288), Sara Ajanovic (11711205), Ronita Luke (14817710), Maureen H. Diaz (10654371), Antonio Sitoe (9536428), Emily S. Gurley (7553270), Afruna Rahman (11507291), Samba O. Sow (7242887), Dianna M. Blau (10928687), Bukiwe Nana Thwala (13132760), Cynthia G. Whitney (10928684), Shams El Arifeen (7326068), Shabir A. Madhi (7457735), Zachary J. Madewell (8190897), Milagritos D. Tapia (3723349), Sulaiman Sannoh (14817713), Ikechukwu U. Ogbuanu (3391520), Rosauro Varo (4962418), J. Anthony G. Scott (11507303), Richard Omore (2636782), Sana Mahtab (11507273), Lola Madrid (3157581), Roosecelis B. Martines (12189872), Cheick B. Traore (14817707), James Bunn (373779), Alim Swarray-Deen (14255906), Kitiezo Aggrey Igunza (13132748), Inacio Mandomando (2806633), Nega Assefa (317612), Vicky L. Baillie (11507297), Muntasir Alam (3411581), Henry Badji (13229388)   +40 more
core   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Severe Maternal Outcomes and Quality of Maternal Health Care in South Ethiopia

International Journal of Women's Health, 2022
Tesfalidet Beyene,1,2 Catherine Chojenta,3 Roger Smith,4 Deborah Loxton3 1Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, NSW, Australia; 2College of Medicine and Health Sciences, Wollega University, Nekemte, Oromia ...
Beyene T, Chojenta C, Smith R, Loxton D
doaj  

Could a simple antenatal package combining micronutritional supplementation with presumptive treatment of infection prevent maternal deaths in sub-Saharan Africa? [PDF]

, 2007
BACKGROUND: Reducing maternal mortality is a key goal of international development. Our objective was to determine the potential impact on maternal mortality across sub-Saharan Africa of a combination of dietary supplementation and presumptive treatment ...
Collin, Simon M, Pittrof Rudiger, Baggaley, Rebecca F, Rebecca F Baggaley, Collin, SM, Filippi, Veronique, Collin Simon M, Veronique Filippi, Baggaley Rebecca F, Pittrof, Rudiger, Filippi, V, Baggaley, RF, Rudiger Pittrof, Filippi Veronique, Simon M Collin, Pittrof, R   +15 more
core   +2 more sources

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source

Ischemic Postconditioning Protects Aged Myocardium Against Ischemia/Reperfusion Injury by Regulating Mitochondrial Dynamics via piR‐4913

Advanced Science, EarlyView.
A tiny RNA tips the scales of cardiac injury in aging. piR‐4913 recruits OGT to Drp1 and drives its O‐GlcNAcylation at Thr604, promoting excessive mitochondrial fission that aggravates ischemia‐reperfusion injury. Ischemic postconditioning silences this pathway to restore mitochondrial balance and protect the aged myocardium, revealing piR‐4913 as a ...
Xiangyu Zhao, Yanchun Li, Nan Li, Juan Zhang, Xiaolong Ma, Fei Yang, Ruihan Long, Yining Tian, Yichen Wang, Shengchao Ma, Huiping Zhang, Yideng Jiang   +11 more
wiley   +1 more source

Causes of maternal deaths in non-SCD population(A). (B)Causes of maternal deaths in SCD.

, 2013
Causes of maternal deaths in non-SCD population(A). (B)Causes of maternal deaths in SCD.
Projestine S. Muganyizi (283767), Hussein Kidanto (283770)   +1 more
core   +1 more source

Interactions between maternal provisioning and natural selection on seed mass fluctuate across heat waves

American Journal of Botany, EarlyView.
Abstract Premise Changing climates are leading to more frequent and severe heat waves, potentially threatening plant populations. Both acclimation to stress and selection for heat‐escape or heat‐resistance phenotypes occur during heat waves. However, plastic responses and selection do not necessarily interact cohesively—even producing trait responses ...
Lana F. Gaspard, Elissa Harb, Stacy D. Holt Jr., Courtney M. Patterson, Nicholas J. Kooyers   +4 more
wiley   +1 more source