Results 61 to 70 of about 10,787,772 (302)

Maternal response to environmental unpredictability [PDF]

, 2015
This study was funded by a postdoctoral fellowship to MB (SFRH/BPD/82259/2011) and with a “Bolsista CAPES/BRASIL,” (Project A058/2013) to AMVMS.Mothers are expected to use environmental cues to modify maternal investment to optimize their fitness ...
Lopes, Isabel, Janeiro, Maria João, Catia Venâncio, Soares, Amadeu M.V.M., Morrissey, Michael Blair, Amadeu M.V.M. Soares, Janeiro Silva, Maria Joao, Isabel Lopes, Soares, Amadeu M. V. M., Barbosa, Miguel, Michael Blair Morrisey, Maria João Janeiro, Miguel Barbosa, Morrisey, Michael Blair, Venâncio, Catia, Barbosa, Miguel; id_orcid   +15 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane, Anna Capasso, Chiara Arpaia, Adele D’Amico, Emilio Albamonte, Federica Trucco, Maria Sframeli, Riccardo Masson, Francesca Magri, Luca Bello, Romina Venditti, Claudia Dosi, Michela Catteruccia, Michele Tosi, Claudio Bruno, Sonia Messina, Giacomo Comi, Elena Pegoraro, Valeria A. Sansone, Eugenio Mercuri   +19 more
wiley   +1 more source

Polyphagous predatory rove beetles (Coleoptera: Staphylinidae) induce winged morphs in the pea aphid Acyrthosiphon pisum (Hemiptera: Aphididae)

European Journal of Entomology, 2013
A number of aphid species have been shown to produce winged dispersal morphs in the presence of natural enemies. Previous studies tested specialized aphid predators such as ladybirds or lacewing larvae.
Adalbert BALOG, Mohsen MEHRPARVAR, Wolfgang W. WEISSER   +2 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Cohesin and the Maternal Age Effect [PDF]

Cell, 2005
During meiosis in human oocytes, chromosome nondisjunction increases with maternal age, leading to disorders such as Down's syndrome. In a recent study in Nature Genetics, Hodges et al. (2005) show that mice with a mutation in the meiosis-specific cohesin protein SMC1beta exhibit age-dependent defects in meiosis.
Gilliland, William D., Hawley, R. Scott
openaire   +2 more sources

Maternal dopamine exposure provides offspring starvation resistance in Daphnia

Ecology and Evolution, 2022
The neurotransmitter dopamine has been shown to play an important role in modulating behavioral, morphological, and life history responses to food abundance.
Semona Issa, Safa Chaabani, Alexandros G. Asimakopoulos, Veerle L. B. Jaspers, Sigurd Einum   +4 more
doaj   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

COMPONENTES DE (CO)VARIANZA PARA PESO AL DESTETE DE GANADO CEBÚ BERMEJO CUBANO

Tropical and Subtropical Agroecosystems, 2011
Con el objetivo de estimar los componentes de (co)varianza del peso al destete en el ganado Cebú bermejo cubano se tomó una muestra de 5120 registros de animales hembras y machos que nacieron entre los años 1988 y 2007 en tres hatos ubicados en las ...
Narciso Ysac Avila, Alejandro Palacios, José Luis Espinoza, Ariel Guillen, Rafael De Luna, Danilo Guerra   +5 more
doaj  

Influences of maternal care on chicken welfare [PDF]

, 2016
This review was funded by a BBSRC Future Leader Fellowship to Joanne Edgar.In domestic chickens, the provision of maternal care strongly influences the behavioural development of chicks.
Suzanne Held, Jones, Charlotte, Edgar, Joanne, Troisi, Camille, Held, Suzanne, Joanne Edgar, Held, Suzanne D E, Charlotte Jones, Camille Troisi   +8 more
core   +1 more source