Results 41 to 50 of about 1,285,364 (360)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Clinical experience of the expanded carrier screening for recessive genetic diseases in a large cohort study in Southern central China

Scientific Reports
Recessive monogenic disorders represent a significant cause of congenital malformations and disabilities in pediatric populations. The present study aims to provide the first comprehensive assessment of clinical experience with expanded carrier screening
Lu pan, Haiyan Luo, Tingting Huang, Huizhen Yuan, Yongyi Zou, Qing Lu, Baitao Zeng, Pengpeng Ma, Yan Yang, Ting Huang, Danping Liu, Bicheng Yang, Yanqiu Liu, Jun Zou, Fen Fu   +14 more
doaj   +1 more source

Temporal effects of maternal psychological distress on child mental health problems at ages 3, 5, 7 and 11: analysis from the UK Millennium Cohort Study [PDF]

, 2019
Background: Psychological distress is common among women of childbearing age, and limited longitudinal research suggests prolonged exposure to maternal distress is linked to child mental health problems.
Chittleborough, Catherine, Deighton, Jessica, Hope, Steven, Law, Catherine, Lynch, John, Maika, Amelia, Micali, Nadia, Mittinty, Murthy, Pearce, Anna   +8 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Correlation between ocular residual astigmatism and anterior corneal astigmatism in children with low and moderate myopia

BMC Ophthalmology, 2022
Background To assess the correlation between ocular residual astigmatism and anterior corneal astigmatism in children with low and moderate myopia. Methods Refractive astigmatism was determined by subjective manifest refraction.
Jian Lin, Dexiang An, Yun Lu, Dongmei Yan   +3 more
doaj   +1 more source

Improving adolescent maternal health

South African Medical Journal, 2015
Each year thousands of adolescent girls and young women in South Africa (SA) become pregnant and many die from complications related to pregnancy and childbirth.
Baxter, C, Moodley, D
openaire   +5 more sources

Child Health, Maternal Marital and Socioeconomic Factors, and Maternal Health [PDF]

Journal of Family Issues, 2012
Although maternal socioeconomic status and health predict in part children’s future health and socioeconomic prospects, it is possible that the intergenerational association flows in the other direction such that child health affects maternal outcomes.
Dana, Garbarski, Whitney P, Witt
openaire   +2 more sources

Maternal Diet Quality and the Health Status of Newborns [PDF]

, 2022
Jitka Pavlíková, Antonín Ambrož, K. Hoňková, Irena Chvojkova, Radim J. Šrám, Pavel Rössner, Jan Topinka, Tomáš Gramblička, Ondrej Parizek, Denisa Parizkova, Jana Schmuczerová, Jana Pulkrábová, Andrea Rössnerová   +12 more
openalex   +1 more source

Quality of maternal healthcare in India:Has the National Rural Health Mission made a difference? [PDF]

, 2011
Despite a five decade old Family Welfare programme, India still continues to contribute almost a quarter of the global estimates of maternal morbidity and mortality.
Nair, Harish, Panda, Rajmohan
core   +2 more sources