Results 71 to 80 of about 1,103,489 (292)

Constructing maternal morbidity - towards a standard tool to measure and monitor maternal health beyond mortality. [PDF]

, 2016
BACKGROUND: Maternal morbidity is a complex entity and its presentation and severity are on a spectrum. This paper describes the conceptualization and development of a definition for maternal morbidity, and the framework for its measurement: the maternal
Jose Guilherme; Say, van den Broek, Nynke, Maternal Morbidity Working Group, Doris; Tuncalp, Cecatti, JG, Nynke van den Broek, Veronique; von Dadelszen, Cecatti, J G, Peter; van den Broek, von Dadelszen, Peter, Maria; Filippi, Nynke; Cecatti, Chou, Chou, D, Veronique Filippi, Peter von Dadelszen, Filipi, V, Jose Guilherme Cecatti, Tabassum Firoz, von Dadelszen, P, Doris Chou, Barreix, Maria, Tunçalp, Özge, Firoz, T, Say, Lale, Say, L, van den Broek, N, Barreix, M, Tuncalp, Oezge, Cecatti, Jose Guilherme, Tabassum; Barreix, Lale, von Dadelszen, Peter; id_orcid, Maria Barreix, Filippi, Veronique, Cecatti, Jose G, Oezge; Firoz, ?, ?, Chou, Doris, Filippi, V, null null, Firoz, Tabassum, Özge Tunçalp, Lale Say, Tunçalp, Ö   +44 more
core   +2 more sources

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source

Aetiology and use of antibiotics in pregnancy-related infections: results of the WHO Global Maternal Sepsis Study (GLOSS), 1-week inception cohort

Annals of Clinical Microbiology and Antimicrobials
Background Pregnancy-related infections are important contributors to maternal sepsis and mortality. We aimed to describe clinical, microbiological characteristics and use of antibiotics by source of infection and country income, among hospitalized women
Carolina C. Ribeiro-do-Valle, Mercedes Bonet, Vanessa Brizuela, Edgardo Abalos, Adama Baguiya, Fernando Bellissimo-Rodrigues, Mihaela Budianu, Lucian Puscasiu, Marian Knight, David Lissauer, Catherine Dunlop, Shevin T. Jacob, Sadia Shakoor, Luis Gadama, Bouchra Assarag, João Paulo Souza, Jose G. Cecatti, the WHO GLOSS research group   +17 more
doaj   +1 more source

Model‐Informed Evaluation of Hydroxyurea Exposure During Lactation

Clinical Pharmacology &Therapeutics, EarlyView.
Hydroxyurea is a cornerstone therapy for sickle cell anemia; however, evidence guiding its use during lactation remains limited. This study aimed to develop a population pharmacokinetic (PK) model to characterize hydroxyurea disposition in maternal plasma and breast milk, and to quantify infant exposure under clinically relevant breastfeeding scenarios.
Anhar Hosawi, Kei Irie, Min Dong, Julie Ware, Russell Ware, Tomoyuki Mizuno   +5 more
wiley   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Maternal smoking during pregnancy and appetite control in offspring [PDF]

, 2003
Aims: Intrauterine exposure to tobacco smoke products has been associated with long-term neurobehavioral effects. Modified appetite control might explain the recently observed association between maternal smoking during pregnancy and obesity in offspring.
Ehlin, A G C, Kries, R. von, Toschke, A M, Montgomery, S. M., Ehlin, Anna G. C., Ekbom, A, Montgomery, S M, Toschke, A. M., Ekbom, A., von Kries, R, Toschke, AM, Ehlin, AGC, von, Kries R, Montgomery, SM   +13 more
core   +1 more source

Phase I Evaluation of Siltartoxatug, a First‐in‐Class Anti‐Tetanus Monoclonal Antibody: Safety, Pharmacokinetics and Pharmacodynamics in Healthy Australian and Chinese Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Siltartoxatug, a first‐in‐class monoclonal antibody targeting tetanus toxin for post‐exposure prophylaxis, was evaluated in two phase I trials in Australian and Chinese healthy adults. In these randomized, double‐blind, placebo‐controlled, dose‐escalation studies, participants received a single intramuscular injection of siltartoxatug (10–250 μg/kg) or
Xinyu Liu, Zhigang Liu, Xiaohu Kuang, Yueming Wang, Xiaoyi Liu, Jiyuan Ding, Xia Zhou, Xin Zhou, Qianyu Liang, Meizhuo Zhang, Hao Zhao, Qingqing Tan, Weihong Zheng, Huaxin Liao, Charlotte Lemech, Wanmei Wang   +15 more
wiley   +1 more source

Maternal tobacco, cannabis and alcohol use during pregnancy and risk of adolescent psychotic symptoms in offspring [PDF]

, 2009
Background Adverse effects of maternal substance use during pregnancy on fetal development may increase risk of psychopathology. Aims To examine whether maternal use of tobacco, cannabis or alcohol during pregnancy increases risk of offspring ...
David Gunnell, Dieter Wolke, Jeremy Horwood, Kate Thomas, Andrew Thompson, Gunnell, David, Lewis, Glyn, Harrison, Glynn, Stanley Zammit, Paulo Menezes, Hollis, Chris, Glyn Lewis, Wolke, Dieter, Zammit, Stanley, Horwood, Jeremy, Thomas, Kate, Thompson, Andrew D., Menezes, Paulo, Chris Hollis, Glynn Harrison, Thompson, Andrew   +20 more
core   +1 more source

Model‐Informed Dose Optimization of Anakinra in Preterm Neonates Implications for Safe and Effective Dosing

Clinical Pharmacology &Therapeutics, EarlyView.
Anakinra, an interleukin‐1 receptor antagonist, shows promise for reducing inflammatory complications of premature birth. However, the pharmacokinetics (PK) of anakinra in neonates has not been characterized, limiting evidence‐based dosing. This study aimed to develop a population PK model for anakinra to guide dosing in preterm neonates.
Jia Li, David K. Metz, Elys Green, Gergely Toldi, Robert Galinsky, Megan Clark, Rebecka Atkinson, Ina Rudloff, Josephine C. Owen, Sara K. DiSimone, Samuel C. Forster, Steven X. Cho, Atif Majid, Graeme R. Polglase, Marcel Favilla, Pramod Pharande, Atul Malhotra, Calum T. Roberts, Scott H. Stansfield, Arvind Sehgal, Kenneth Tan, Alistair J. Gunn, Philip J. Berger, Alex Veldman, Rod W. Hunt, Claudia A. Nold‐Petry, Marcel F. Nold, Carl M. J. Kirkpatrick   +27 more
wiley   +1 more source

Indicators of extreme maternal morbidity in a university clinic of third level of complexity. a retrospective evaluation

Revista Ciencias Biomédicas, 2012
Introduction: The vigilance of the extreme maternal morbidity is a valid institutionalstrategy as mechanism to impact on maternal mortality rate and to improve theperinatal outcomes of obstetric patients that are critically ill.Objective: To estimate the
Bello-Álvarez Laura Margarita, Vásquez-Dielafeaut Doris, Rojas-Suarez José Antonio, Sará-Fortich Patricia, Cogollo-González Marysabel, Jaramillo Juan José, Dueñas-Castell Carmelo   +6 more
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