Results 51 to 60 of about 7,111,062 (308)

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source

Social and health system factors associated with maternal mortality in Eastern and Western China: Population health estimates using provincial-level data.

PLoS Medicine
BackgroundGlobally, maternal mortality is off track in achieving the Sustainable Development Goals by 2030. Over the past two decades, China has dramatically reduced maternal mortality in more developed (eastern) and less developed (western) regions.
Xiaojing Zeng, Dongjian Yang, Shiyang Li, Xiaolin Hua, Yanlin Wang, Jun Zhang, Zhiwei Liu   +6 more
doaj   +1 more source

Interactions between maternal provisioning and natural selection on seed mass fluctuate across heat waves

American Journal of Botany, EarlyView.
Abstract Premise Changing climates are leading to more frequent and severe heat waves, potentially threatening plant populations. Both acclimation to stress and selection for heat‐escape or heat‐resistance phenotypes occur during heat waves. However, plastic responses and selection do not necessarily interact cohesively—even producing trait responses ...
Lana F. Gaspard, Elissa Harb, Stacy D. Holt Jr., Courtney M. Patterson, Nicholas J. Kooyers   +4 more
wiley   +1 more source

Effectiveness of the Expanded Maternal and Neonatal Survival Program in the Reduction of Maternal Mortality in Tegal, Central Java [PDF]

, 2016
Background: Maternal mortality rate is one of the sensitive indicators of population health in a country. Various measures have been implemented to reduce maternal mortality rate, including the Expanding Maternal And Neonatal Survival (EMAS) program ...
Demartoto, Argyo, Karina Cibro, Adeyle Datna, Sulaeman, Endang Sutisna   +2 more
core  

Achieving the Millennium Development Goal of reducing maternal mortality in rural Africa: an experience from Burundi. [PDF]

, 2012
OBJECTIVES: To estimate the reduction in maternal mortality associated with the emergency obstetric care provided by Médecins Sans Frontières (MSF) and to compare this to the fifth Millennium Development Goal of reducing maternal mortality.
Nicolai, M, Van den Boogaard, W, Manzi, M, Harries, AD, Christaens, B, Manirampa, J, Harries, A D, Ndelema, B, Van den Bergh, R, Nyandwi, G, Zachariah, R, Tayler-Smith, K, De Plecker, E, Goetghebuer, S, Lambert, V, Reid, T, Kabangu, A   +16 more
core   +1 more source

Systematic Cardiac Phenotyping of Patients With Copy Number Variants in the 15q11.2 Breakpoint 1 to Breakpoint 2 Region: A Retrospective Cohort Study From Nine Pediatric Cardiac Centers

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Microdeletions impacting 15q11.2 breakpoint (BP) 1 to BP2, adjacent to the Prader–Willi critical region, have previously described neuropsychiatric associations, with potential low penetrance presentations of congenital heart disease (CHD) also identified.
Morgan B. Wright, Maria B. Padua, Lindsey R. Helvaty, Kim L. McBride, Gabrielle Geddes, Vidu Garg, Seema R. Lalani, Stephanie Burns Wechsler, Jennelle C. Hodge, Benjamin J. Landis, Stephanie M. Ware   +10 more
wiley   +1 more source

Trends in maternal and child health in China and its urban and rural areas from 1991 to 2020: a joinpoint regression model

Scientific Reports
The long-term trends in maternal and child health (MCH) in China and the national-level factors that may be associated with these changes have been poorly explored.
Xin‒yue Wang, Bei‒bei Zhang, Yuan‒yi Cao, Qian Xue, Qin Ye, Yuan‒sheng Li, Shu‒yuan Wang, Yuan‒wei Ma, Yan‒que Sun, Jun‒hui Zhang   +9 more
doaj   +1 more source

The safe motherhood referral system to reduce cesarean sections and perinatal mortality - a cross-sectional study [1995-2006]

Reproductive Health, 2011
Background In 2000, the eight Millennium Development Goals (MDGs) set targets for reducing child mortality and improving maternal health by 2015. Objective To evaluate the results of a new education and referral system for antenatal/intrapartum care as a
Rudge Marilza VC, Maestá Izildinha, Moura Paula MSS, Rudge Cibele VC, Morceli Glilciane, Costa Roberto AA, Abbade Joelcio, Peraçoli José C, Witkin Steven S, Calderon Iracema MP   +9 more
doaj   +1 more source

Age-specific maternal mortality rate across different periods.

, 2020
Age-specific maternal mortality rate across different periods.
Tippawan Liabsuetrakul (6646876), Biniam Getachew (6991433), Yirgu Gebrehiwot (5632835), Shama Virani (276828)   +3 more
core   +1 more source

Systematic Review of Females With Intellectual Disability and MECP2 Duplication

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT MECP2 Duplication Syndrome (MDS) is a rare, X‐linked neurodevelopmental disorder typically affecting males. Females with MDS have been reported and are compiled here. We conducted a systematic review (PROSPERO CRD420250652426) of PubMed, EMBASE, and Google Scholar extracting individual participant data.
Paul Malik, Davut Pehlivan, Cary Fu, Antonio F. Martinez‐Monseny, Mar O'Callaghan, Judith Armstrong, Sarika U. Peters, Steven T. Lee, Timothy J. Feyma, Paola Mian, Christine Coquery   +10 more
wiley   +1 more source