Results 141 to 150 of about 788,741 (309)

Dual‐Mode Type I/II Photosensitization of a Stable Mesoporous Hydrogen‐Bonded Organic Framework for Antibacterial Therapy

Advanced Science, EarlyView.
A π‐conjugated donor–acceptor PDI monomer undergoes hydrogen‐bonded self‐assembly to form a robust mesoporous framework. The ordered molecular arrangement promotes efficient intersystem crossing and charge separation, leading to simultaneous Type I and Type II reactive oxygen species generation with a high singlet oxygen quantum yield.
Yi‐Lun Cheng, Hui Yuan, Yuhang Li, Zi‐Yu Wang, Rui Wang, Qi Yin, Xue‐Ning Ren, Miao Zheng, Yi Zeng, Tian‐Fu Liu, Zaisheng Ye   +10 more
wiley   +1 more source

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Social Determinants of Smoke Exposure During Pregnancy: Findings From Waves 1 & 2 of the Population Assessment of Tobacco and Health (PATH) Study [PDF]

, 2018
Maternal smoking during pregnancy (MSDP) and secondhand smoke (SHS) exposure are associated with a myriad of negative health effects for both mother and child.
Do, Elizabeth K., Fuemmeler, Bernard F., Green, Tiffany L., Prom-Wormley, Elizabeth C.   +3 more
core   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

DNA methylation associated with postpartum depressive symptoms overlaps findings from a genome-wide association meta-analysis of depression [PDF]

, 2019
Background Perinatal depressive symptoms have been linked to adverse maternal and infant health outcomes. The etiology associated with perinatal depressive psychopathology is poorly understood, but accumulating evidence suggests that understanding inter ...
Kinser, Patricia A., Kirkpatrick, Robert M., Lapato, Dana M., Roberson-Nay, Roxann, Webb, Bradley T., York, Timothy P.   +5 more
core   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

The Role of Artificial Intelligence in Medication Management for Older Adults: A Systematic Review

AGING MEDICINE, EarlyView.
Artificial intelligence enhances medication management for older adults by improving adherence, personalizing treatment, and predicting risks. Despite benefits, challenges remain in usability, trust, ethics, and system integration. Successful adoption requires user‐centered design, ethical safeguards, and seamless healthcare integration to ensure safe,
Dipak Chandra Das, Moustaq Karim Khan Rony, Shovit Dutta, MD. Sami Al Zubair Zujbe, Tapan Bhattacharjee, Niloy Debnath, Shabbir Abdullah Maruf, Chowdhury Galib Mortuza, Farhana Rahman, Akash Das   +9 more
wiley   +1 more source

Perceived Barriers and Supports to Medication Adherence in Type 2 Diabetes: A Qualitative Study of Patients with and without a Zero-Dollar Copay Health Plan Benefit

Patient Preference and Adherence
Debra Winberg,1,2 Sarita V Panchang,3 Elizabeth Nauman,3 Brice L Mohundro,4 Tiange Tang,2 Eboni G Price-Haywood,5 Stephen Onufrak,6 Lizheng Shi,1 Alessandra N Bazzano7 1Department of Health Management and Policy, Georgetown University, Washington, DC ...
Winberg D, Panchang SV, Nauman E, Mohundro BL, Tang T, Price-Haywood EG, Onufrak S, Shi L, Bazzano AN   +8 more
doaj  

Maternal and Neonatal Outcomes in Pre-eclampsia and Normotensive Pregnancies

Thai Journal of Obstetrics and Gynaecology, 2010
Objective: To compare the maternal and neonatal outcomes of pregnancies with pre-eclampsia to those with normotensive. Materials and Methods: Cases were defined as pregnancies with pre-eclampsia who delivered between January 1st, 2009 and ...
Ussanee Sangkomkamhang, Malinee Laopaiboon , Pisake Lumbiganon   +2 more
doaj  

Ecological niche modeling reveals habitat differentiation and climatic vulnerability in two imperiled, sympatric southern Appalachian carnivorous plants

American Journal of Botany, EarlyView.
Abstract Premise Understanding the habitat requirements of imperiled flora is critical for informing ex situ conservation practices, designing effective reintroduction strategies, and understanding how climate change will impact such species, especially in montane regions with high levels of environmental heterogeneity. In southern Appalachia, USA, the
Nicholas J. Chang, Lauren Eserman, Amanda Carmichael, Adam B. Smith, Xingwen Loy, Emily E. D. Coffey, James Ojascastro   +6 more
wiley   +1 more source