Results 31 to 40 of about 528,073 (147)

Increased Brown Adipose Tissue Thermogenesis in Phenylketonuria. [PDF]

MedComm (2020)
In phenylketonuria (PKU), elevated phenylalanine (Phe) increases hepatic fibroblast growth factor 21 (FGF21) and thyroid hormones, enhancing brown adipose tissue (BAT) thermogenesis in patients. Central FGF21 reproduces this phenotype in rodents via reduced hypothalamic AMP‐activated protein kinase (AMPK) activity in the ventromedial nucleus of the ...
López-Rey N, Cabaleiro A, Pata MP, Peyrou M, Estévez-Salguero Á, Fernández-Sanmartín P, Morgan DA, Ferreira V, Sánchez-Pintos P, Folgueira C, Diéguez C, Urisarri A, González-García I, Seoane LM, Rahmouni K, Villarroya F, Couce ML, Nogueiras R, López M.   +18 more
europepmc   +2 more sources

Clinical application of non-invasive prenatal diagnosis of phenylketonuria based on haplotypes via paired-end molecular tags and weighting algorithm

BMC Medical Genomics, 2021
Background Phenylketonuria (PKU) is a metabolic disease that can cause severe and irreversible brain damage without treatment. Methods Here we developed a non-invasive prenatal diagnosis (NIPD) technique based on haplotypes via paired-end molecular tags ...
Dai Peng, Zhao Ganye, Sun Gege, Xia Yanjie, Liu Ning, Kong Xiangdong   +5 more
doaj   +1 more source

Congenital heart disease and its journey from dental plaque to arterial plaque

Journal of International Clinical Dental Research Organization, 2016
Congenital heart disease is mostly found in children, approximately around 7–10% from overall heart diseases. The etiology is multifactorial but reported associations include untreated maternal diabetes, phenylketonuria, intake of retinoic acid last but ...
Vinathi Reddy Kankara, Nagireddy Ravindra Reddy   +1 more
doaj   +1 more source

#174 : Preconception Risk Factors and Interventions to Prevent Adverse Maternal, Perinatal, and Child Health Outcomes

Fertility & Reproduction, 2023
Background and Aims: Preconception period allows to explore and intervene how women’s health conditions and certain risk factors could affect the mother and newborn’s health, once she becomes pregnant.
Zahra Ali Padhani, Jodie Avery, Gizachew Tessema, Negin Mirzaei Damabi, Zohra Lassi   +4 more
doaj   +1 more source

Maternális phenylketonuria [Maternal phenylketonuria]

, 2013
Phenylketonuriában szenvedő várandós anya vérének emelkedett phenylalanin-koncentrációja a magzatra teratogén hatással van, embryo-foetopathiát okoz. Élveszülés esetén a kórkép jellemzői az intrauterin sorvadás, az általában jelentős fokú pszichomotoros ...
János Bókay, Kiss, Erika, Kiss Erika, Szőnyi László, Erika Simon, Erika Kiss, Bókay János, Simon Erika, Bókay, János, László Szőnyi, Szőnyi, László, Simon, Erika   +11 more
core   +1 more source

Attitudes of Chinese maternal and child health professionals toward termination of pregnancy for fetal anomaly: a cross-sectional survey

Frontiers in Public Health, 2023
ObjectivesThis study explores the attitudes of Chinese maternal and child health professionals toward the termination of pregnancy for fetal anomaly (TOPFA) based on four case scenarios and further identifies the factors that influence their attitudes ...
Ying Wu, Yanlin Liu, Yanlin Liu, Xiaomin Wang, Xiaomin Wang, Yuqiong Zhong, Xin Zhang, Xin Zhang, Dan Luo, Xing Liu, Xing Liu   +10 more
doaj   +1 more source

The first study of successful pregnancies in Chinese patients with Phenylketonuria

BMC Pregnancy and Childbirth, 2020
Background Since the inception of newborn screening programs in China in the 1990s, pregnancy among patients with inherited, metabolic disorders has become more common.
Lin Wang, Fang Ye, Hui Zou, Kundi Wang, Zhihua Chen, Qin Hui, Bingjuan Han, Chun He, Xiaowen Li, Ming Shen   +9 more
doaj   +1 more source

Association Between Preoperative Dyslipidemia and the Prognosis of Patients With Endometrial Cancer: A Retrospective Cohort Study

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 10, October 2026.
ABSTRACT Endometrial cancer (EC) is closely related to metabolic disorders. We aimed to investigate whether preoperative dyslipidemia independently affects the prognosis of patients with EC. One hundred and ninety‐four women diagnosed with EC by pathology and who had undergone standardized surgical treatment at the Affiliated Hospital of Jining Medical
Song Li, Rong‐He Sun, Qing Chen, Zeng‐Shu Huang, Yun‐Fei Wang, Chang‐Zhong Li   +5 more
wiley   +1 more source

Supplementary data for: Phenylketonuria in a microbial world, chapter 7

, 2023
This folder contains the supplementary data visualizations of Phenylketonuria in a microbial world, chapter 7: Increased risk of developing sleep disorders in phenylketonuria: An inquiry in five European ...
Falcao Salles lab, Van der Zee lab, Van Spronsen, Francjan J., van der Goot, Els; id_orcid, Center for Liver, Digestive and Metabolic Diseases (CLDM), van der Goot, Els   +5 more
core   +2 more sources

Engineering Bacteria for Medicine: Delivery, Diagnosis, and Therapy

iMetaMed, Volume 2, Issue 3, September 2026.
ABSTRACT With rapid advances in synthetic biology and genetic engineering, genetically engineered bacteria (GEB) have emerged as a promising platform for biological therapy, addressing key limitations of conventional drug delivery systems and demonstrating significant clinical potential.
Shiyu Xia, Guiling Fu, Xiaoyue Ding, Wen Yang, Ruijie Bai, Yawei Cai, Jing xuan Zhang, Yanxia Wei, Conghui Han, Yi‐Zhou Gao, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source