Results 31 to 40 of about 3,357 (148)

The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary

Autism Research, Volume 19, Issue 5, May 2026.
ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley   +1 more source

The Expanding Role of Gene Sequencing in Shaping Fetal Therapies: Clinical and Ethical Considerations

Prenatal Diagnosis, Volume 46, Issue 5-6, Page 623-635, May 2026.
ABSTRACT In utero interventions are transformative in addressing genetic and anatomic conditions during fetal development. Next generation sequencing enables early genetic testing, playing a pivotal role in prenatal decision‐making by supporting risk stratification, precise and timely diagnosis, which directly informs eligibility for fetal surgical and
Matthew A. Shear, Beltran Borges, Billie R. Lianoglou, Tony Lum, Emma Canepa, Jennifer L. Cohen, Julia E. H. Brown, Akos Herzeg   +7 more
wiley   +1 more source

A Method to Estimate Health Effects Based on Error‐Prone Simulated Environmental Exposure: An Application to a Multi‐Country Study on Birthweight and Fine Particulate Matter

GeoHealth, Volume 10, Issue 5, May 2026.
Abstract Earth System Models provide spatiotemporally continuous environmental exposure data but remain underused in environmental epidemiology because of uncertainty from measurement errors. We developed a novel latent‐variable approach to correct for measurement error characterized by spatiotemporal error covariance, which was derived from ...
Jinting Guo, Ning Kang, Jianyu Deng, Minghao Qiu, Tao Xue   +4 more
wiley   +1 more source

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, Volume 2, Issue 2, April 2026.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

Effect of maternal blood phenylalanine level on mouse maternal phenylketonuria offspring

, 2001
Click on the DOI link below to access the article (may not be free).The genetic mouse model BTBR-Pah(enu2) was used to more thoroughly investigate the pathogenesis of maternal phenylketonuria (MPKU).
Cho, Sangbun, McDonald, J. David
core   +1 more source

Risk of Major Congenital Malformations Associated With the First‐Trimester Exposure to Antipsychotics: A Large Claims Database Study

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT This study aimed to evaluate the risk of major congenital malformations (MCMs) associated with first‐trimester exposure to antipsychotics, using a large claims database in Japan. This retrospective cohort study was based on data from a large claims database in Japan. We used a large claims database from 2010 to 2019.
Ryo Obara, Takamasa Sakai, Tomofumi Ishikawa, Kei Morishita, Motohiko Adomi, Azusa Hara, Saya Kikuchi, Natsuko Kobayashi, Noriyuki Iwama, Genki Shinoda, Aoi Noda, Masatsugu Orui, Mami Ishikuro, Hiroaki Tomita, Nariyasu Mano, Shinichi Kuriyama, Taku Obara   +16 more
wiley   +1 more source

Nexus of Whey Proteins, Gut Dysbiosis, and Colonic Health

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Whey proteins possess antimicrobial and prebiotic properties that modulate gut microbiota by promoting beneficial bacteria like Bifidobacterium while suppressing pathogens. This modulation enhances short‐chain fatty acid production and strengthens intestinal barrier integrity, potentially alleviating dysbiosis‐related conditions such as colitis and ...
Tolulope Joshua Ashaolu, Chi‐Ching Lee, Ozgur Tarhan, Ali Rashidinejad, Seid Mahdi Jafari   +4 more
wiley   +1 more source

The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. [PDF]

, 2008
This paper reviews current knowledge on the role of the long-chain polyunsaturated fatty acids (LC-PUFA), docosahexaenoic acid (DHA, C22:6n-3) and arachidonic acid (AA, 20:4n-6), in maternal and term infant nutrition as well as infant development ...
Alexandre Lapillonne, Tamas Decsi, S. Forsyth, Niels J Secher, Berthold Koletzko, Willatts, Peter, MD Berthold Koletzko, C. Agostoni, Hansjosef Bö Hles, N. J. Secher, NN, NN, Szajewska, Hania, Lapillonne, Alexandre, Irene Cetin, Carlo Agostoni, Ricardo Uauy, Putet, Guy, Eric Lien, Forsyth, Stewart, I. Hoesli, Uauy, Ricardo, Mike Symonds, Dudenhausen, Joachim W, Uauy Dagach-Imbarack, Ricardo, Cristina Campoy, W. Holzgreve, Stewart Forsyth, Hania Szajewska, T. Decsi, Irene Hoesli, Koletzko, Berthold, Lien, Eric, J. W. Dudenhausen, Peter Willatts, Secher, Niels J, C. Campoy, Guy Putet, B. Koletzko, H. Szajewska, E. Lien, G. Putet, Joachim W Dudenhausen, Dudenhausen, Joachim W., Boehles, Hansjosef, Hoesli, Irene, Böhles, Hansjosef, Decsi, Tamas, Dupont, Cristophe, Cristophe Dupont, M. Symonds, Campoy, Cristina, Secher, Niels J., Symonds, Mike, P. Willatts, Cetin, Irene, A. Lapillonne, I. Cetin, Agostoni, Carlo, H. Böhles, Wolfgang Holzgreve, Holzgreve, Wolfgang, R. Uauy, World Association of Perinatal Medicine Dietary Guidelines Worki, C. Dupont   +63 more
core   +1 more source

The Creation of a Weight of Evidence Scoring Database for Risk Factors for Adverse Impacts to Birth Outcomes Using Expert Elicitation

Birth Defects Research, Volume 118, Issue 1, January 2026.
ABSTRACT Background Adverse birth outcomes are important public health measures and account for a substantial public health burden. There is considerable diversity of these health endpoints, as well as in the many factors suspected or recognized to increase their risk.
Paul J. Villeneuve, Ann Aschengrau, Michelle L. Bell, Yang Cao, Mark Elwood, Guy Eslick, Shelley Harris, Leeka Kheifets, Babak Khoshnood, Robert Norman, Nelson Pace, Johan Reutfors, Jeremy M. Schraw, Jose R. Suarez‐Lopez, Gunnar Toft, R. Douglas Wilson, Christopher R. Kirman, Tyler Carneal, Sean M. Hays   +18 more
wiley   +1 more source

Targeted Carrier Screening for Thalassemia, Hereditary Deafness, and Spinal Muscular Atrophy: A Feasible Approach for Preventing Birth Defects in China's Community Healthcare System

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
Current carrier screening primarily focuses on high detection rates and broad testing ranges. We approach the issue from the perspective of a community physician, evaluating the suitability of carrier screening based on factors such as cost, ease of report interpretation, and compliance issues.
Zhihui Wang, Wenjing Bai, Xiaohe Cai, Sheng Huang, Jiangzhong Zeng, Xiaoting Liang, Xutao Hong   +6 more
wiley   +1 more source