Results 261 to 270 of about 4,864,908 (360)

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Introducing an integrated maternity care pathway for women with a history of small-for-gestational-age: Evaluation of its effect on care process and clinical outcomes. [PDF]

PLoS One
Hermans ACM, Spaan J, Hermus MAA, Hietkamp AM, Visser J, Franx A, van der Kooy J.   +6 more
europepmc   +1 more source

cuteHap: Haplotype‐Aware Structural Variant Detection in Phased Long‐Read Sequencing Data

Advanced Science, EarlyView.
cuteHap is a haplotype‐aware structural variant detection method designed for phased long‐read sequencing. By employing self‐adaptive clustering and credibility‐prioritized beam search algorithms, cuteHap generates accurate haplotype‐resolved calls and outperforms state‐of‐the‐art tools.
Shuqi Cao, Yadong Liu, Miao Cui, Runtian Gao, Weimin Guo, Guohua Wang, Yadong Wang, Tao Jiang   +7 more
wiley   +1 more source

An Exploration of Maternal Health Care Providers' Perspectives on Respectful Maternity Care in the United States: A Scoping Review Protocol. [PDF]

Health Equity
Ofori-Parku CY.
europepmc   +1 more source

Maternity and Perinatal Care Unit [PDF]

, 2009
伊奈 志帆美, 吉田 丈俊, 塩崎 有宏, 宮脇 利男, 廣川 慎一郎, 廣野 恵一, 米田 哲, 長谷川 徹, 魚谷 英之   +8 more
core   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Effectiveness of a respectful maternity care program in a Guatemalan indigenous region rural hospital: a quasi-experimental study. [PDF]

Front Glob Womens Health
Ikezoe H, Horiuchi S, Girón M.
europepmc   +1 more source

Maternity and Perinatal Care Center [PDF]

, 2016
仲岡 佐智子, 伊吹 圭二郎, 吉田 丈俊, 小浦 詩, 小澤 綾佳, 川﨑 裕香子, 牧本 優美, 猪又 智実, 田村 賢太郎, 米田 哲, 齋藤 和由   +10 more
core   +2 more sources

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Respectful maternity care experiences of South Asian refugees in the US: a qualitative study. [PDF]

Front Public Health
Smith DC, Thumm EB, Tien NCG, Kissler K.
europepmc   +1 more source