Results 81 to 90 of about 4,864,908 (360)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Epidemiology of and risk factors for neonatal candidemia at a tertiary care hospital in western China

BMC Infectious Diseases, 2016
Background The prevalence and clinical characteristics of neonatal candidemia are poorly understood in western China. The aim of our study was to evaluate the epidemiological features of neonatal candidemia in the Liuzhou Maternity and Child Healthcare ...
Jichang Chen, Yongjiang Jiang, Ba Wei, Yanling Ding, Shaolin Xu, Peixu Qin, Jinjian Fu   +6 more
doaj   +1 more source

Prevalence of antibiotic resistance genes bla-CTX-M, bla-SHV, bla-TEM in enterobacteria strains isolated from perinatal center patients

Эпидемиология и вакцинопрофилактика, 2022
Relevance A common mechanism of resistance is the synthesis of enzymes that inactivate the antibiotic (AB). Since its discovery at the end of the 20th century, ESBLs have spread widely throughout the world.
A. V. Ustyuzhanin, G. N. Chistyakova, I. I. Remizova, A. A. Makhanyok   +3 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Initiating C.H.E.W. at Maternity Care Coalition [PDF]

, 2017
The purpose of this project is to provide access to healthy and affordable foods to the families involved in Maternity Care Coalition’s Early Head Start program as means to reduce obesity in the 0-3 year old children.
Brawer, MPH, PhD, Rickie, Wicklum, Haley
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Maternity Care and Consumer-Driven Health Plans [PDF]

, 2007
Compares out-of-pocket costs of maternity care under consumer-driven health plans (CDHP) to a traditional health insurance plan. Explores related factors including prenatal care coverage and unpredictability of costs for delivery and hospital ...
Alina Salganicoff, Karen Pollitz, Mila Kofman, Usha Ranji   +3 more
core  

Access and utilisation of maternity care for disabled women who experience domestic abuse:a systematic review [PDF]

, 2014
BACKGROUND: Although disabled women are significantly more likely to experience domestic abuse during pregnancy than non-disabled women, very little is known about how maternity care access and utilisation is affected by the co-existence of disability ...
AC Huth-Bocks, AL Coker, Anne Lazenbatt, BA Bailey, BJ Taylor, C Begley, CA Kopac, CA Kopac, Caroline Bradbury-Jones, Confidential Enquiry into Maternal and Child Health (CEMACH), CP Ferri, D Lawer, D Sumilo, D Walsh, D Walsh-Gallagher, DA Brownridge, DE Stewart, E Slayter, E Smith, E Stark, EM Shadigian, F Bradley, G Hague, GJ Prosman, HG Kim, HI Gasser, HM Government, Home Office, J Barroso, J Bruce, J Nixon, J Radford, J Requejo, J Webster, Jenna P Breckenridge, JL Jasinski, John Devaney, Julie Taylor, K Finlayson, KA Barrett, KA Kendall-Tackett, L Bacchus, L Taggart, LE Powers, M Mitra, MA Nosek, MA Nosek, MA Nunes, NI Gavin, NICE, R O’Reilly, RM Andersen, Royal College of Midwives, Royal College of Nursing, RS Barbour, S Lipsky, S Pandey, SB Plummer, SL Desmaris, T Kroll, Thilo Kroll, TL Tallieu, United Nations, World Health Organization, World Health Organization   +64 more
core   +7 more sources

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source