Anxiolytic Medication Use in Low- Middle- and High-Income Countries: A World Mental Health Surveys Report. [PDF]
ABSTRACT Background Anxiolytic medications, particularly benzodiazepines, are widely prescribed, giving impetus to long‐standing debates about how often these agents should be employed in clinical practice. There are, however, few cross‐country studies of the pharmacoepidemiology of these agents. We report on the frequency of anxiolytic medication use,
Stein DJ +31 more
europepmc +2 more sources
Structural insights into SARS-CoV-2 nonstructural protein 4 (nsp4) biogenesis. [PDF]
Abstract The SARS‐CoV‐2 virus—responsible for the COVID‐19 pandemic—requires a replication–transcription complex (RTC) for efficient RNA synthesis and viral propagation. One critical RTC component is nonstructural protein 4 (nsp4), a multipass transmembrane (TM) protein implicated in endoplasmic reticulum (ER) membrane rearrangements and double ...
Acosta-Cáceres JM +7 more
europepmc +2 more sources
Mediterranean Tomato Landraces Exhibit Genotype-Specific Transcriptomic Responses to Water Stress. [PDF]
ABSTRACT Drought stress is a critical limitation to crop production, particularly in Mediterranean climates. The molecular response of drought adaptation in crops is variable and coordinated in leaves and roots. To understand the molecular basis of drought tolerance in tomato, the transcriptomic responses of two drought‐tolerant Mediterranean landraces
Juan-Cabot A +5 more
europepmc +2 more sources
Biomechanical mapping of tumor growth: A novel method to quantify glioma infiltration and mass effect [PDF]
Abstract Background Glioblastoma (GBM) growth can alter surrounding brain tissue through location‐dependent physiological changes. Two main growth phenotypes—(I) infiltrative, characterized by diffuse invasion with minimal mass effect, and (II) proliferative, characterized by pronounced tissue compression—are recognized, but their quantitative ...
López‐Mateu C +7 more
europepmc +2 more sources
Nonlinear mechanisms in passive microwave devices [PDF]
Premi extraordinari doctorat curs 2010-2011, àmbit d’Enginyeria de les TICThe telecommunications industry follows a tendency towards smaller devices, higher power and higher frequency, which imply an increase on the complexity of the electronics ...
Rocas Cantenys, Eduard
core +4 more sources
Tolerance to mutations in the foot-and-mouth disease virus integrin-binding RGD region is different in cultured cells and in vivo and depends on the capsid sequence context. [PDF]
Engineered RNAs carrying substitutions in the integrin receptor-binding Arg-Gly-Asp (RGD) region of foot-and-mouth disease virus (FMDV) were constructed (aa 141-147 of VP1 capsid protein) and their infectivity was assayed in cultured cells and suckling
Baranowski, Eric +4 more
core +3 more sources
El dibujo poeta de un Miralles que experimenta y crea
Para entender la arquitectura de Enric Miralles es necesario comprender como la dibujaba, era su proceso proyectual el que definía su arquitectura y el dibujo, el instrumento principal en este devenir creativo. Su dibujo era siempre de intención y fue su
Salvador Gilabert Sanz +2 more
doaj +1 more source
Background: Perinatal depression is a major public health problem, with an estimated prevalence of approximately 15% during the first postpartum year. Despite the high prevalence of postpartum depression, there is no consensus regarding assessment and ...
María F. Rodríguez-Muñoz +13 more
doaj +1 more source
The merger history of massive spheroids since z~1 is size independent [PDF]
Using a compilation of 379 massive (stellar mass M > 10^{11} M_Sun) spheroid-like galaxies from the near-infrared Palomar/DEEP-2 survey, we have probed, up to z~1, whether the presence of companions depends on the size of the host galaxies.
Barro, G. +6 more
core +2 more sources
LOS PROYECTOS DE REFORMA PENAL EN ESPAÑA: UN RETROCESO HISTÓRICO
El Proyecto de reforma del Código Penal español va a suponer, de ser aprobado, un retroceso histórico. Prácticamente todos los principios penales se van a ver muy afectados, cuando no negados.
Juan Carlos Carbonell Mateu
doaj +2 more sources

