Results 31 to 40 of about 7,529,557 (207)
Pediatric Blood &Cancer, EarlyView.ABSTRACT The medical burdens of sickle cell disease (SCD) and transfusion‐dependent β‐thalassemia (TDT) are chronic and cumulative, even in children. Yet the effects expand beyond medications and healthcare visits due to their impacts on school attendance, academic performance, and peer engagement.
Mary Ann Etling +2 more
wiley +1 more source
On the Notion of Interestingness in Automated Mathematical Discovery [PDF]
, 2000 We survey five mathematical discovery programs by looking in detail at the discovery processes they illustrate and the success they’ve had. We focus on how they estimate the interestingness of concepts and conjectures and extract some common notions ...
Walsh T +8 more
core +1 more source
, 2023 (1) Background: The aim of the study is to develop a set of models for managing a fleet of complex technical systems with metrological support, allowing the simulation and management at all the stages of the life cycle of the complex technical systems ...
Denis Ershov +3 more
core +1 more source
Bi-directional grid constrained stochastic processes and their applications in mathematical finance [PDF]
, 2022 A statement of the research problem can be expressed, simply as, can bi-directional grid trading (BGT) be distilled into a mathematical model that can then be used to demonstrate that the corresponding grid trading problem (GTP) leads to ruin at a much ...
Taranto, Aldo
core +1 more source
Essays on Mathematical Geography
, 1986 A collection of essays intended to show the range of power in applying pure mathematics to human systems. There are two types of essay: those which employ tranditional mathematical proof, and those which do not.
Arlinghaus, Sandra Lach
core +5 more sources
Scientific ReportsAlterations in energy metabolism are recognized as a hallmark of cancer. Experimental evidence shows that oncogenes play a key role in the reprogramming of metabolism.
Mareike Simon +4 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Mathematical modeling of tumor growth and treatment [PDF]
, 2014 Using mathematical models to simulate dynamic biological processes has a long history. Over the past couple of decades or so, quantitative approaches have also made their way into cancer research.
Chaplain, Mark A. J. +2 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source