Results 41 to 50 of about 223,007 (265)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Modeling of strain and filtration properties of a semi-finished leather product

Journal of Leather Science and Engineering, 2021
A study on deformation and filtration properties of a leather semi-finished product after chrome tanning are presented. The analytical dependences of compressive load on compressive (recovery) strain and moisture content of a leather semi-finished ...
A. Amanov, S. R. Khurramov, G. A. Bahadirov, A. Abdukarimov, T. Y. Amanov   +4 more
doaj   +1 more source

Mathematical Modelling for Predicting Thermal Properties of Selected Limestone

Buildings, 2022
Due to a lack of geotechnical and geothermal studies on Jordanian limestone, this paper aims to provide the thermal properties, including thermal conductivity, thermal diffusivity, and specific heat, using the Hot Disk Transient Plane Source (TPS) 2200 ...
Abdulla A. Sharo, Samer R. Rabab'ah, Mohammad O. Taamneh, Hussein Aldeeky, Haneen Al Akhrass   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Mathematical Properties of the Binomial-Poisson Distribution

Journal of Applied Sciences and Environmental Management
This study conducts a thorough analytical exploration of the Binomial-Poisson distribution, a compound probability model where the number of Binomial trials follows a Poisson distribution. Through application of the compound distribution methodology and
A. A. Ayenigba, D. A. Afariogun, O. M. Ajao, I. K. Adebayo   +3 more
doaj   +4 more sources

Qualitative properties of mathematical model for data flow

Networks & Heterogeneous Media, 2021
<p style='text-indent:20px;'>In this paper, properties of a recently proposed mathematical model for data flow in large-scale asynchronous computer systems are analyzed. In particular, the existence of special weak solutions based on propagating fronts is established.
Hauck, CD, Herty, M, Visconti, G
openaire   +6 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source