Results 251 to 260 of about 1,155,431 (277)

Flash Photodynamic Therapy – How the Saturation of Photosensitizer Absorption Enables Selective and Deeper Tumor Treatments

open access: yesAdvanced Science, EarlyView.
FLASH‐PDT uses strongly‐absorbing photosensitizers and pulsed lasers to saturate the photosensitizer absorption at ≈1‐cm tissue depths. This allows for the generation of [ROS] above the necrosis threshold level for tumors, while maintaining [ROS] in peritumoral tissues below that threshold, even when the tumor‐to‐peritumoral tissue ratio is as low as 2.
Luis G. Arnaut   +3 more
wiley   +1 more source

NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression

open access: yesAdvanced Science, EarlyView.
A double‐negative feedback loop is identified in TNBC where NUSAP1 bridges HIF and DAXX via its microtubule‐associated domain (MAD) to recruit SETDB1, repressing HIF transcriptional activity by depositing the H3K9me3 repressive mark on HIF target genes, while HIF itself suppresses NUSAP1.
Yating Du   +14 more
wiley   +1 more source

MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis

open access: yesAdvanced Science, EarlyView.
This study uncovers a size‐dependent adhesion paradigm, demonstrating that the glycocalyx protein MUC15 suppresses pancreatic cancer progression by attenuating integrin activation, focal adhesion assembly, and YAP mechanotransduction. Integrating computational modeling and experimental validation, the work reveals a mechanical mechanism by which MUC15 ...
Simei Zhang   +18 more
wiley   +1 more source

Estimating the transmissibility of the 2025 chikungunya fever outbreak in Foshan, China: a modelling study. [PDF]

open access: yesInfect Dis Poverty
Zhao Y   +10 more
europepmc   +1 more source

Deep Learning‐Assisted Fingerprint‐Inspired Flexible Pressure Sensor for Tension Monitoring in Carbon Fiber Production

open access: yesAdvanced Science, EarlyView.
A fingerprint‐inspired piezoresistive sensor is developed for real‐time tension monitoring of wide‐width carbon fiber bundles. Fabricated by laser engraving, it shows high sensitivity, broad range, and durability under high‐temperature conditions. Integrated with a CNN achieving 96% anomaly classification accuracy, the system provides a practical ...
Xiaohua Wu   +10 more
wiley   +1 more source

Surface Adhesion Engineering for Armored Metasurfaces and Beyond

open access: yesAdvanced Science, EarlyView.
Targeting primary causes of dysfunctionality in optical systems, an “armored” metasurface is developed based on Persson's model and Hertzian theory, enabling anti‐dust, anti‐scratch, anti‐impact, and anti‐water, heat resistance capabilities, alongside excellent optical antireflection performance.
Lianwei Chen   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy