Results 31 to 40 of about 78 (78)
Application of Surrogate Modeling in Stochastic Analysis of an Ogee Spillway Structure
International Journal of Mechanical System Dynamics, EarlyView.ABSTRACT This study investigates the hydraulic performance of an Ogee spillway under varying flow rate conditions, gate opening heights, and spillway widths. Numerical simulations using Flow‐3D, incorporating the (k‐ε) turbulence model and Large Eddy Simulation (LES), were employed alongside surrogate models using MATLAB codes and LP‐TAU to predict ...
Kaywan Othman Ahmed +2 more
wiley +1 more source
Parameterized Local Reduced Order Model of Stimulated Volume Evolution in Reservoirs
International Journal for Numerical and Analytical Methods in Geomechanics, EarlyView.ABSTRACT Real‐time simulation of large‐scale geomechanics problems, such as hydraulic dilation stimulation, is computationally expensive as they must span multiple spatial and temporal length scales, often including nonlinearities and thermo‐hydromechanical processes.
Saeed Hatefi Ardakani, Robert Gracie
wiley +1 more source
A conservative numerical scheme for the multilayer shallow‐water equations on unstructured meshes
Quarterly Journal of the Royal Meteorological Society, EarlyView.An energy‐conserving scheme is derived for the multilayer shallow water model, making use of the direct connection between energy conservation and the skew symmetry of the Poisson bracket for the model. A new mechanism is proposed to prevent layer interface outcropping.
Qingshan Chen
wiley +1 more source
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
Monogenic Retinal Diseases Associated With Genes Encoding Phototransduction Proteins: A Review
Clinical &Experimental Ophthalmology, Volume 53, Issue 3, Page 260-280, April 2025.ABSTRACT Phototransduction, the process by which captured photons elicit electrical changes in retinal rod and cone cells, represents the first neuronal step in vision and involves interactions between several highly specialised proteins. Pathogenic variants in genes encoding many of these proteins can give rise to significant vision impairment ...
Wendy M. Wong, Omar A. Mahroo
wiley +1 more source
Isosurface Extraction for Signed Distance Functions using Power Diagrams
Computer Graphics Forum, EarlyView.Abstract Contouring an implicit function typically considers function values in the vicinity of the desired level set, only. In a recent string of works, Sellán at al. have demonstrated that signed distance values contain useful information also if they are further away from the surface.
M. Kohlbrenner, M. Alexa
wiley +1 more source
Inverse Simulation of Radiative Thermal Transport
Computer Graphics Forum, EarlyView.Abstract The early phase of urban planning and architectural design has a great impact on the thermal loads and characteristics of constructed buildings. It is, therefore, important to efficiently simulate thermal effects early on and rectify possible problems.
C. Freude +5 more
wiley +1 more source
Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera
The FEBS Journal, EarlyView.Here, we report KTX207, a previously undescribed cereblon‐based PDE4 PROTAC that can specifically target PDE4D shortform for degradation. We showed that KTX207 could improve selectivity, potency and enable a long‐lasting effect when used at a sub‐nanomolar concentration.
Yuan Yan Sin +16 more
wiley +1 more source
Pediatric Obesity, EarlyView.Summary Background and Objectives To examine whether changes in the Mediterranean Diet (MD) or any of its MD food groups modulate the genetic susceptibility to obesity in European youth, both in cross‐sectional and longitudinal analyses. Methods For cross‐sectional analysis, 1982 participants at baseline, 1649 in follow‐up 1 (FU1) and 1907 in follow‐up
Miguel Seral‐Cortes +20 more
wiley +1 more source
Measure‐valued processes for energy markets
Mathematical Finance, Volume 35, Issue 2, Page 520-566, April 2025.Abstract We introduce a framework that allows to employ (non‐negative) measure‐valued processes for energy market modeling, in particular for electricity and gas futures. Interpreting the process' spatial structure as time to maturity, we show how the Heath–Jarrow–Morton approach can be translated to this framework, thus guaranteeing arbitrage free ...
Christa Cuchiero +3 more
wiley +1 more source