Results 201 to 210 of about 961,565 (270)

Engineering Adenine Deaminase TadA for Precise and PAM‐Flexible Point Mutagenesis and Gradient‐Tuning Endogenous Protein Design

Advanced Science, EarlyView.
Base editing enables precise nucleotide substitutions but limited by bystander editing. This study engineers plant base editors by fusing optimized TadA variants with PAM‐flexible SpRY nickase, enabling A‐to‐G, C‐to‐T, and dual‐base conversions in a highly condensed window (≤3 nucleotides). Additionally, TadDBE (TadA Dual‐Base Editor)‐mediated directed
Kangli Sun, Si Cheng, Nan Chai, Jianing Mi, Ruixiang Zhang, Qian Qian, Zhiye Zheng, Ke Chen, Dongchang Zeng, Xin Peng, Mengyuan Shen, Degui Zhou, Qinlong Zhu, Qi Liu, Jiantao Tan   +14 more
wiley   +1 more source

AI-assisted technology optimization in disability support systems using fuzzy rough MABAC decision-making. [PDF]

Sci Rep
Ahmmad J, Al-Dayel OA, Khan MA, Mahmood T.   +3 more
europepmc   +1 more source

Programmable DNA‐Based Molecular Neural Network Biocomputing Circuits for Solving Partial Differential Equations

Advanced Science, EarlyView.
This research introduces an augmented matrix‐based DNA molecular neural network to achieve molecular‐level solving of biological Brusselator PDEs. Crucial innovations include: (i) an augmented matrix‐based DNA molecular neural network, enabling multidimensional parameter integration through DNA strand displacement cascades and iterative weight ...
Yijun Xiao, Alfonso Rodríguez‐Patón, Jianmin Wang, Pan Zheng, Tongmao Ma, Tao Song   +5 more
wiley   +1 more source

On statistical analysis of topological indices and heat of formation for titanium diboride network. [PDF]

Sci Rep
Ismail R, Saher R, Hanif MF, Hanif MF, Siddiqui MK, Fufa SA.   +5 more
europepmc   +1 more source

Topological Singularities and Edge‐State Coupling Enable Robust on‐Chip Slow Light

Advanced Science, EarlyView.
This work demonstrates the first experimental observation of a topological quantum‐interference‐like effect in a 1D on‐chip system, utilizing two topological mechanisms for robust slow light. Topological charges ensure immunity to parameter deviations, while edge states provide robustness against disturbances.
Yuqian Wang, Shengyu Hu, Zhiwei Guo, Jie Jiang, Yaping Yang, Cuicui Lu, Hong Chen   +6 more
wiley   +1 more source

New bounds of the smoothing parameter for lattices. [PDF]

PLoS One
Guo H, Liu F, Wang L, Tian K.
europepmc   +1 more source

The Potential of Cognitive‐Inspired Neural Network Modeling Framework for Computer Vision

Advanced Science, EarlyView.
In article number 202507730, Guorun Li, Lei Liu, Yuefeng Du, and co‐workers present a cognitive modeling framework (CMF) to bridge the ‘representation gap’ and ‘conceptual gap’ between cognitive theory and vision deep neural networks (VDNNs). The research findings provide new insights and solid theoretical support for VDNN modeling inspired by ...
Guorun Li, Lei Liu, Xiaoyu Li, Yuefeng Du, Zhenghe Song, Xiuheng Wu   +5 more
wiley   +1 more source

Bifurcation analysis, modulation instability and dynamical analysis of soliton solutions for generalized (3 + 1)-dimensional nonlinear wave equation with m-fractional operator. [PDF]

Sci Rep
Algolam MS, Roshid MM, Alsharafi M, Younis B, Aldwoah K, Osman O.   +5 more
europepmc   +1 more source

Protein Spatial Structure Meets Artificial Intelligence: Revolutionizing Drug Synergy–Antagonism in Precision Medicine

Advanced Science, EarlyView.
This review comprehensively examines the applications of protein three‐dimensional structures and artificial intelligence in investigating drug synergistic and antagonistic effects. The research findings provide compelling evidence for the precision treatment of cancer and metabolic diseases, thereby promoting the development of personalized medicine ...
Anqi Lin, Chang Che, Aimin Jiang, Chang Qi, Antonino Glaviano, Zhijie Zhao, Zhirou Zhang, Zaoqu Liu, Ziyao Zhou, Quan Cheng, Shuofeng Yuan, Peng Luo   +11 more
wiley   +1 more source

"In Mathematical Language": On Mathematical Foundations of Quantum Foundations. [PDF]

Entropy (Basel)
Plotnitsky A.
europepmc   +1 more source