Results 201 to 210 of about 547,109 (305)

A model‐informed clinical trial simulation tool with a graphical user interface for Duchenne muscular dystrophy

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
Abstract Quantitative model‐based clinical trial simulation tools play a critical role in informing study designs through simulation before actual execution. These tools help drug developers explore various trial scenarios in silico to select a clinical trial design to detect therapeutic effects more efficiently, therefore reducing time, expense, and ...
Jongjin Kim   +10 more
wiley   +1 more source

Open and Closed Loop Approaches for Energy Efficient Quantum Optimal Control

open access: yesAdvanced Quantum Technologies, EarlyView.
Concepts from quantum thermodynamics and optimal control are blended to derive a theoretical framework to quantify and minimize the energetic cost of a pulse for unitary synthesis. Two complementary techniques (based on GRAPE and Reinforce‐DRL) are implemented as open‐source software that co‐optimizes the fidelity and energetic cost within quantum ...
Sebastiaan Fauquenot   +2 more
wiley   +1 more source

Fixed‐Time Adaptive Neural Control for Physical Human–Robot Collaboration With Time‐Varying Workspace Constraints

open access: yesInternational Journal of Robust and Nonlinear Control, EarlyView.
ABSTRACT Effective physical human–robot collaboration (pHRC) requires strict safety guarantees since robots coordinate with human actions in a shared workspace. Moreover, compliance is essential, enabling robots to adjust their stiffness and behavior in response to human interaction forces. This paper presents a novel fixed‐time adaptive neural control
Yuzhu Sun   +6 more
wiley   +1 more source

Implementing complex nucleic acid circuits in living cells. [PDF]

open access: yesSci Adv
Sun J   +13 more
europepmc   +1 more source

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