Results 181 to 190 of about 1,955,102 (244)

The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels

Advanced Science, EarlyView.
In breast cancer (BC), NUMB loss of function (LOF) is common and mainly driven by protein hyper‐degradation. The CRL7FBXW8 complex is the E3 ligase responsible for NUMB degradation. Inhibition of CRL7FBXW8 in NUMB‐LOF BC cells restores NUMB levels, and decreases the number of cancer stem cells and tumorigenic ability in vivo. Targeting CRL7FBXW8 offers
Simone Sabbioni, Maria Grazia Filippone, Letizia Amadori, Stefano Confalonieri, Roberta Bonfanti, Stefano Capoano, Ivan Nicola Colaluca, Stefano Freddi, Giovanni Bertalot, Giovanni Fagà, Elisa Zagarrí, Mario Varasi, Rosalind Helen Gunby, Ciro Mercurio, Salvatore Pece, Pier Paolo Di Fiore, Daniela Tosoni   +16 more
wiley   +1 more source

Thermodynamics of Intrinsic Reaction Coordinate (IRC) Chemical Reaction Pathways. [PDF]

Entropy (Basel)
Weinhold F.
europepmc   +1 more source

Stereotyped Subclones Revealed by High‐Density Single‐Cell Lineage Tracing Support Robust Development

Advanced Science, EarlyView.
Based on a well‐established in vitro directed differentiation model and an integrated analysis of high‐density cell lineage trees (CLTs) and single‐cell transcriptomes, it is demonstrated that many subclones are formed by sub‐CLTs resembling each other in terms of both cell type compositions and topological structures.
Xiaoyu Zhang, Zizhang Li, Jingyu Chen, Wenjing Yang, Xingxing He, Peng Wu, Feng Chen, Ziwei Zhou, Chenze Ren, Yuyan Shan, Xiewen Wen, Vassily A. Lyubetsky, Leonid Yu. Rusin, Xiaoshu Chen, Jian‐Rong Yang   +14 more
wiley   +1 more source

Analyses of an age structure HIV/AIDS compartmental model with optimal control theory. [PDF]

Sci Rep
Teklu SW, Guya TT, Kotola BS, Lachamo TS.   +3 more
europepmc   +1 more source

A Programmed DNA Dynamic Assembly‐Guided Molecular Amplifier for Authentic Information Decryption

Advanced Science, EarlyView.
This study presents a DNA‐based constitutional dynamic network (CDN) with adaptive thresholds for secure information decryption. The system self‐calibrates output patterns, ensuring reproducibility and accuracy, and integrates molecular amplifiers for expanded message capacity and precise DNA sensing.
Ning Yang, Jie Zhou, Fengying Yuan, Yajuan Liu, Jia Zhang, Ying Zhuo, Yu Ouyang, Yaqin Chai, Pu Zhang, Ruo Yuan   +9 more
wiley   +1 more source

Time-lagged recurrence: A data-driven method to estimate the predictability of dynamical systems. [PDF]

Proc Natl Acad Sci U S A
Dong C, Faranda D, Gualandi A, Lucarini V, Mengaldo G.   +4 more
europepmc   +1 more source

Self‐Maintainable Electronic Materials with Skin‐Like Characteristics Enabled by Graphene‐PEDOT:PSS Fillers

Advanced Science, EarlyView.
Graphene‐PEDOT:PSS fillers revolutionize soft electronics by transforming jelly‐like materials into skin‐like systems with self‐healing, heat‐responsiveness, and multiplex sensing capabilities. This novel material exhibits exceptional printability, flexibility, and adhesiveness, enabling seamless integration into bioelectronics and tissue‐cyborganic ...
Morteza Alehosseini, Firoz Babu Kadumudi, Sinziana Revesz, Parham Karimi Reikandeh, Jonas Rosager Henriksen, Tiberiu‐Gabriel Zsurzsan, Jon Spangenberg, Alireza Dolatshahi‐Pirouz   +7 more
wiley   +1 more source

Bessel statistical convergence: New concepts and applications in sequence theory. [PDF]

PLoS One
Ibrahim IS, Yousif MA, Mohammed PO, Baleanu D, Zeeshan A, Abdelwahed M.   +5 more
europepmc   +1 more source

Epileptiform Activity and Seizure Risk Follow Long‐Term Non‐Linear Attractor Dynamics

Advanced Science, EarlyView.
This study leverages the HAVOK framework to model long‐term, nonlinear attractor dynamics underlying epileptiform activity and seizure risk in epilepsy patients. By identifying key forcing mechanisms driving chaotic transitions, the findings improve seizure risk forecasting over multi‐day cycles and provide a pathway for personalized, data‐driven ...
Richard E Rosch, Brittany Scheid, Kathryn A Davis, Brian Litt, Arian Ashourvan   +4 more
wiley   +1 more source

Advancements in integral inequalities of Ostrowski type via modified Atangana-Baleanu fractional integral operator. [PDF]

Heliyon
Rahman G, Samraiz M, Shah K, Abdeljawad T, Elmasry Y.   +4 more
europepmc   +1 more source