Results 91 to 100 of about 3,984,242 (310)
Advanced Science, EarlyView.Long‐term hippocampal place‐code dynamics are investigated using calcium imaging across weeks of maze navigation. Analyses reveal a novelty‐irrelevant Single‐Field Evolution Rule (SFER), where active fields promote persistence and inactive fields decline.
Cong Chen +10 more
wiley +1 more source
Advanced Science, EarlyView.A minimal computational model of cellular aggregate formation in neurodegenerative disease, encompassing two competing processes: cell‐autonomous and cell‐to‐cell triggers of aggregation, is presented. Despite its simplicity, the model can reproduce the aggregate patterns observed in post‐mortem brain images from the primary tauopathy Progressive ...
Shih‐Huan Huang +8 more
wiley +1 more source
Advanced Science, EarlyView.An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu +11 more
wiley +1 more source
Accurate Generation of Conformational Ensembles for Intrinsically Disordered Proteins with IDPFold
Advanced Science, EarlyView.In brief: IDPFold predicts the conformational ensembles of intrinsically disordered proteins (IDPs) from their amino acid sequences. The atomic structures generated by IDPFold offer crucial insights into the intricate relationship between IDP structures and their diverse biological functions.2 Abstract Intrinsically disordered proteins (IDPs) play ...
Junjie Zhu +10 more
wiley +1 more source
Advanced Science, EarlyView.This study reconstructs the driving force field of fibroblast‐to‐neuron transdifferentiation from sparse single‐cell images by decomposing it into flux and time‐dependent potential gradient, extending the landscape‐flux framework to non‐steady‐state systems.
Chudan Yu +3 more
wiley +1 more source
Design Principles for Deployable Fibers Inspired by Hagfish Defense
Advanced Science, EarlyView.Hagfish slime deploys fibers from coiled skeins to form an ultra‐dilute, water‐trapping network. Inspired by this mechanism, design principles are established for synthetic skeins, fabricated with tightly coiled fibers that unravel under flow. These synthetic skeins demonstrate deployable fibrous networks, highlighting generalizable strategies for ...
Mohammad Tanver Hossain +8 more
wiley +1 more source
Advanced Science, EarlyView.Integrating hierarchical physicochemical features via a bio‐inspired design, the DAISY framework robustly predicts T‐cell receptor binding, significantly outperforming state‐of‐the‐art models on unseen epitopes. It uniquely offers visual interpretability via Score‐CAM visualizations and profound clinical relevance, correlating with T‐cell expansion ...
Yajing Yuan +9 more
wiley +1 more source
Advanced Science, EarlyView.FLASH‐PDT uses strongly‐absorbing photosensitizers and pulsed lasers to saturate the photosensitizer absorption at ≈1‐cm tissue depths. This allows for the generation of [ROS] above the necrosis threshold level for tumors, while maintaining [ROS] in peritumoral tissues below that threshold, even when the tumor‐to‐peritumoral tissue ratio is as low as 2.
Luis G. Arnaut +3 more
wiley +1 more source