Results 21 to 30 of about 2,378,574 (249)
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif +17 more
wiley +1 more source
Multiple perspectives on the concept of conditional probability [PDF]
, 2012 Conditional probability is a key to the subjectivist theory of probability; however, it plays a subsidiary role in the usual conception of probability where its counterpart, namely independence is of basic importance.
Borovcnik, Manfred
core
Justifying Definitions in Mathematics—Going Beyond Lakatos [PDF]
, 2009 This paper addresses the actual practice of justifying definitions in mathematics. First, I introduce the main account of this issue, namely Lakatos's proof-generated definitions.
Werndl, Charlotte
core +1 more source
Optimal Reinsurance to Minimize the Probability of Drawdown under the Mean-Variance Premium Principle: Asymptotic Analysis [PDF]
, 2023 In this paper, we consider an optimal reinsurance problem to minimize the probability of drawdown for the scaled Cram´er-Lundberg risk model when the reinsurance premium is computed according to the mean-variance premium principle.
Liang, Xiaoqing +7 more
core +1 more source
Probability in Logic, Mathematics and Science
Dialectica, 1949 Die Definition der Wahrscheinlichkeit wird aus drei Gesichtspunkten beleuchtet. I. Beim mathematischen a) als das klassische Verhältnis der Zahl der dem Ereignis günstigen Fälle zu jener aller gleichmöglichen, b) als die relative Häufigkeit des Ereignisses innerhalb einer festen Zahl von Wiederholungen des Versuches, c) als ein vollständig additives ...
openaire +1 more source
dynoGP: Deep Gaussian Processes for Dynamic System Identification
International Journal of Adaptive Control and Signal Processing, EarlyView.This work introduces a novel class of deep models for system identification, dynamical deep Gaussian processes, which combine the strengths of data‐driven methods, such as those based on neural network architectures, with the ability to output a probability distribution for uncertainty representation.
Alessio Benavoli +3 more
wiley +1 more source
Students' perspectives on the nature of mathematics [PDF]
, 2006 This paper reports on one small component of a much larger study that explored the perspectives of students towards mathematics learning. Students were asked “What do you think maths is all about?” Some students responded in terms of mathematical content.
Taylor, Merilyn +3 more
core +1 more source
A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions
Advanced Engineering Materials, EarlyView.This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice +2 more
wiley +1 more source