Results 131 to 140 of about 740,482 (234)

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

open access: yesAdvanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi   +13 more
wiley   +1 more source

Some applications of the theory of group representations in mathematical physics

open access: yes, 2017
This thesis is concerned mainly with the accidental degeneracy of the n-dimensional anisotropic harmonic oscillator. The general concept of accidental degeneracy is defined, and a summary is given of some of the explanations for it. A description is presented of Mackey's theory of group representations for general semi-direct product groups.
openaire   +1 more source

Hierarchical Artificial Muscle with Nonlinear Elasticity for Antagonistic and Cyclic Robotics

open access: yesAdvanced Science, EarlyView.
We construct hierarchical muscles by plying nylon fibers around a heating wire. The hierarchical muscle shows a J‐shaped passive curve, which shows benefit in antagonistic muscle pair and work accumulation mechanism. We also develop a computational, first‐principle model to understand the physics of both active actuation stroke and passive J‐curve ...
Samuel Tsai   +15 more
wiley   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu   +4 more
wiley   +1 more source

Scalable Manufacturing of Roll‐to‐Roll Slot‐Die Coated Perovskite Solar Cells

open access: yesAdvanced Science, EarlyView.
Roll‐to‐roll (R2R) slot‐die coating is emerging as a scalable pathway for perovskite solar cells. This mini‐review summarizes advances in ink design, drying control, and electrode integration that enable high‐efficiency flexible devices and modules. Challenges in throughput, stability, and sustainable processing are outlined, guiding the translation of
Farshad Jafarzadeh   +5 more
wiley   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

open access: yesAdvanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

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