Results 191 to 200 of about 735,523 (265)

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

open access: yesAdvanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han   +9 more
wiley   +1 more source

An MADM approach for the assessment of eye lenses with fuzziness of using prioritized weighted operators. [PDF]

open access: yesSci Rep
Hu C   +8 more
europepmc   +1 more source

OPTRACE: Optical Imaging–Guided Transplantation and Tracking of Cells in the Mouse Brain

open access: yesAdvanced Science, EarlyView.
OPTRACE establishes an optical, two‐step platform for intracerebral cell therapy. Transparent glass pipettes enable real‐time, image‐guided delivery, while multiplex genetic labeling with two‐photon and bioluminescence readouts supports longitudinal single‐cell tracking and host–graft dynamics.
Jinghui Wang   +10 more
wiley   +1 more source

Convergent and Divergent Connectivity Patterns of the Arcuate Fasciculus in Macaques and Humans

open access: yesAdvanced Science, EarlyView.
This study employs viral‐based single‐neuron tracing and dMRI‐based whole‐brain tractography to investigate arcuate fasciculus (AF) trajectories in macaque monkeys, and compares with the human AF connectome using spectral embedding. Results demonstrate conserved AF topography spanning temporoparietal‐auditory‐frontal pathways across primates, with ...
Jiahao Huang   +17 more
wiley   +1 more source

Principles for Rigorous Design and Application of Synthetic Microbial Communities

open access: yesAdvanced Science, EarlyView.
SynComs are artificially designed to enable inter‐species metabolic interactions, metabolic division of labor, and ecological interactions that can elicit phenotypes like colonization stability and environmental adaptation. This systematic review explores the processes used to construct SynComs, the assessment of the mechanisms of metabolic interaction
Yuxiao Zhang   +21 more
wiley   +1 more source

Recent Advances in Mediator and Proton Relay Usage in Molecular Catalysis

open access: yesAdvanced Science, EarlyView.
The use of electron–proton transfer mediators, redox mediators, and proton relays in synergy with molecular catalysts in energy‐related small‐molecule and organic transformations is discussed, with a focus on recent advances. Linear free‐energy relationship and catalytic Tafel plots provide a systematic foundation for benchmarking these catalytic ...
Yu‐Lin Chi   +3 more
wiley   +1 more source

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