Results 51 to 60 of about 1,002,910 (222)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Mapping Outburst Floods Using a Collaborative Learning Method Based on Temporally Dense Optical and SAR Data: A Case Study with the Baige Landslide Dam on the Jinsha River, Tibet

Remote Sensing, 2021
Outburst floods resulting from giant landslide dams can cause devastating damage to hundreds or thousands of kilometres of a river. Accurate and timely delineation of flood inundated areas is essential for disaster assessment and mitigation.
Zhongkang Yang, Jinbing Wei, Jianhui Deng, Yunjian Gao, Siyuan Zhao, Zhiliang He   +5 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Optimization in the distribution and sequencing of machines in wood harvesting in planted forests

Forest Systems
Aim of study: The objective was to evaluate an optimized model for the distribution and sequencing of machines in tree felling and processing and extraction operations, aiming to reduce unproductive times and gains in production capacity.
Willian Masioli, Julio E. Arce, Carla K. Rodrigues, Nilton C. Fiedler, Eduardo Lopes   +4 more
doaj   +1 more source

Object-Based Classification of Wetlands in Newfoundland and Labrador Using Multi-Temporal PolSAR Data

Canadian Journal of Remote Sensing, 2017
Despite the fact that vast portions of Newfoundland and Labrador (NL) are covered by wetlands, currently there is no provincial inventory of wetlands in the province.
Sahel Mahdavi, Bahram Salehi, Meisam Amani, Jean Elizabeth Granger, Brian Brisco, Weimin Huang, Alan Hanson   +6 more
doaj   +1 more source

Assessing the Quality of Natural Gas Consumption Forecasting: An Application to the Italian Residential Sector

Energies, 2017
(1) Background: The present paper aims at estimating the quality of the forecasts obtained by using one equation models. In particular, the focus is on the effect that the explanatory variables have on the forecasted quantity.
Federico Scarpa, Vincenzo Bianco
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Endotrophin is associated with chronic multimorbidity and all-cause mortality in a cohort of elderly women

EBioMedicine, 2021
Background: The signalling peptide endotrophin is derived through proteolytic cleavage of the carboxyl-terminal during formation of type VI collagen.
Line Mærsk Staunstrup, Cecilie Liv Bager, Peder Frederiksen, Jørn Wulff Helge, Søren Brunak, Claus Christiansen, Morten Karsdal   +6 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source