Results 51 to 60 of about 4,047,300 (256)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Understanding the creep property of heat-resistant Al alloy by analyzing eutectic phase/matrix interface structures

Materials Research Letters, 2023
Interface characteristics are of great importance in mechanical performance for multi-phases heat-resistant Al alloys. Herein, Al3Sc precipitates were created at both Al/Al9FeNi interface and Al matrix inside Al–Fe-Ni eutectic alloy by microalloyed Sc ...
Zeyu Bian, Chen Yang, Hongyi Zhu, Dechao Zhao, Mingliang Wang, Huawei Zhang, Zhe Chen, Haowei Wang   +7 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Structural basis for the contribution of latent TGFβ binding protein to TGFβ latency and activation

Nature Communications
Transforming growth factor-β (TGFβ) is a potent cytokine that controls all aspects of cellular behavior. TGFβ is secreted in complex with its prodomain and latent TGFβ-binding protein-1 (LTBP1), forming the large latent complex (LLC), which through ...
George R. Biggin, Matthew Snee, Yu-Bai Xiao, Catherine Smedley, Alan R. F. Godwin, Rana Dajani, Holly L. Birchenough, Thomas A. Jowitt, Mark A. Travis, Alan M. Roseman, Anna Tarakanova, Clair Baldock   +11 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Minimizing the condition number of a positive definite matrix by completion [PDF]

, 1994
Elsner L, He C, Mehrmann V. Minimizing the condition number of a positive definite matrix by completion. Numerische Mathematik. 1994;69(1):17-23.We consider the problem of minimizing the spectral condition number of a positive definite matrix by ...
Mehrmann, Volker, He, Chunyang, Elsner, Ludwig   +2 more
core   +1 more source

Singular random matrix decompositions: Jacobians. [PDF]

, 2002
For a singular random matrix Y, we find the Jacobians associated with the following decompositions; QR, Polar, Singular Value (SVD), L'U, L'DM and modified QR (QDR).
González Farías, Graciela, Díaz García, José A.   +1 more
core   +1 more source

Low-temperature sequential deposition for efficient inverted perovskite solar cells

Nature Communications
Inverted perovskite solar cell has made significant progress in recent years. Although two-step sequential deposition shows the benefits to obtain higher quality large-size perovskite crystals, the high annealing temperature, which is required to achieve
Mengjiong Chen, Zhenzhen Qin, Ziyang Zhang, Wenxiang Xiang, Yingming Liu, Chuang Tian, Siyuan Chen, Yanbo Wang, Liyuan Han   +8 more
doaj   +1 more source