Results 101 to 110 of about 1,376,709 (310)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Structured matrix methods for computations on Bernstein basis polynomials [PDF]

, 2013
This thesis considers structure preserving matrix methods for computations on Bernstein polynomials whose coefficients are corrupted by noise. The ill-posed operations of greatest common divisor computations and polynomial division are considered, and it
Yang, Ning
core  

Anderson Localization: A Density Matrix Approach

Physical Review X
Anderson localization is a quantum phenomenon in which disorder localizes electronic wave functions. In this work, we propose a new approach to study Anderson localization based on the density matrix formalism. Drawing an analogy to the standard transfer
Ziyue Qi, Yi Zhang, Mingpu Qin, Hongming Weng, Kun Jiang   +4 more
doaj   +1 more source

A Matrix Approach to Vertex-Degree-Based Topological Indices

Mathematics
A VDB (vertex-degree-based) topological index over a set of digraphs H is a function φ:H→R, defined for each H∈H as φH=12∑uv∈Eφdu+dv−, where E is the arc set of H, du+ and dv− denote the out-degree and in-degree of vertices u and v respectively, and φij ...
Roberto Cruz, Carlos Espinal, Juan Rada
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Controllability of matrix second order systems: A trigonometric matrix approach

Electronic Journal of Differential Equations, 2007
Many of the real life problems are modelled as Matrix Second Order Systems, (refer Wu and Duan [19], Hughes and Skelton [10]). Necessary and sufficient condition for controllability of Matrix Second Order Linear (MSOL) Systems has been established by
Raju K. George, Jaita Pankaj Sharma
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

SINGULAR RANDOM MATRIX DECOMPOSITIONS: JACOBIANS. [PDF]

For a singular random matrix Y, we find the Jacobians associated with the following decompositions; QR, Polar, Singular Value (SVD), L´U, L´DM and modified QR (QDR).
Graciela González-Farías, José A. Díaz-García   +1 more
core