Results 91 to 100 of about 1,579,553 (292)

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

What chemical species are responsible for new particle formation and growth in the Netherlands? A hybrid positive matrix factorization (PMF) analysis using aerosol composition (ACSM) and size (SMPS) [PDF]

, 2023
Farhan R. Nursanto, Roy Meinen, Rupert Holzinger, Maarten Krol, Xinya Liu, Ulrike Dusek, Bas Henzing, Juliane L. Fry   +7 more
openalex   +2 more sources

Supplementary material to "Technical note: Identification of chemical composition and source of fluorescent components in atmospheric water-soluble brown carbon by excitation-emission matrix with parallel factor analysis: Potential limitation and application"

, 2022
Tao Cao, Meiju Li, Cuncun Xu, Zhang Xiaosong, Xingjun Fan, Jun Li, Wanglu Jia, Ping’an Peng   +7 more
openalex   +1 more source

Excitation–Emission Matrix Spectroscopy for Analysis of Chemical Composition of Combustion Generated Particulate Matter [PDF]

, 2020
Gaurav Mahamuni, Jay Rutherford, Justin Davis, Eric Molnar, Jonathan D. Posner, Edmund Seto, Gregory V. Korshin, Igor Novosselov   +7 more
openalex   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Upgrading Electrical, Mechanical, and Chemical Properties of CNTs/Polybond® Nanocomposites: Pursuit of Electroconductive Structural Polymer Nanocomplexes

International Journal of Polymer Science, 2016
Electroconductive structural polymer-based nanocomposites (NCs) were prepared by incorporating carbon nanotubes (CNTs) into Polybond (PB) matrix via melt compounding technique. Chemical structure of NCs, investigated via Fourier transform infrared (FTIR)
Muhammad Sarfraz
doaj   +1 more source

Compositional data analysis in archaeometry [PDF]

, 2003
We shall call an n × p data matrix fully-compositional if the rows sum to a constant, and sub-compositional if the variables are a subset of a fully-compositional data set1.
Baxter, MJ, Beardah, CC, Cool, HEM, Jackson, CM   +3 more
core   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Spectrum-effect relationship analysis by binary chromatographic fingerprint to identify components responsible for the antibacterial activity of the essential oil from Curcumae wenyujin

International Journal of Food Properties, 2018
The essential oil from Curcumae wenyujin (CWEO) has antibacterial activity, but the antibacterial compounds in the CWEO have not been identified. The spectrum-effect relationship between chemical compositions and pharmacological activity is regarded as a
Shen Song, Wei-Feng Yao, Xiao-bin Cui, Xiao Liu, Rong-Li Qiu   +4 more
doaj   +1 more source